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Page 1
The C-terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2.
Zingg D, Lin CC, Yemelyanenko J, Wieteska L, Kas SM, Bleijerveld OB, Chao X, Bhin J, Lutz C, Wientjens E, Klarenbeek S, Zanetti G, Annunziato S, Siteur B, van der Burg E, Drenth AP, van de Ven M, Wessels LFA, Altelaar M, Ladbury JE, Jonkers J. Zingg D, et al. Among authors: bleijerveld ob. Cancer Res. 2025 Jun 24. doi: 10.1158/0008-5472.CAN-24-3349. Online ahead of print. Cancer Res. 2025. PMID: 40554806
SRBD1, a highly conserved gene required for chromosome individualization.
Raaijmakers JA, Janssen LME, Mazouzi A, Hondema ALH, Borza R, Fish A, Elbatsh AMO, Kazokaitė-Adomaitienė J, Vaquero-Siguero N, Mayayo-Peralta I, Nahidiazar L, Friskes A, Hoekman L, Bleijerveld OB, Hoencamp C, Moser SC, Jonkers J, Jalink K, Zwart W, Celie PHN, Rowland BD, Perrakis A, Brummelkamp TR, Medema RH. Raaijmakers JA, et al. Among authors: bleijerveld ob. Cell Rep. 2025 Apr 22;44(4):115443. doi: 10.1016/j.celrep.2025.115443. Epub 2025 Mar 18. Cell Rep. 2025. PMID: 40106440 Free article.
Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality.
Bakker NAM, Garner H, van Dyk E, Champanhet E, Klaver C, Duijst M, Voorwerk L, Nederlof I, Voorthuis R, Liefaard MC, Nieuwland M, de Rink I, Bleijerveld OB, Oosterkamp HM, Wessels LFA, Kok M, de Visser KE. Bakker NAM, et al. Among authors: bleijerveld ob. NPJ Breast Cancer. 2025 Jan 23;11(1):5. doi: 10.1038/s41523-025-00721-2. NPJ Breast Cancer. 2025. PMID: 39843922 Free PMC article.
Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma.
Göbel C, Niccolai R, de Groot MHP, Jayachandran J, Traets J, Kloosterman DJ, Gregoricchio S, Morris B, Kreft M, Song JY, Azarang L, Kasa E, Oskam N, de Groot D, Hoekman L, Bleijerveld OB, Kersten MJ, Aslam MA, van Leeuwen F, Jacobs H. Göbel C, et al. Among authors: bleijerveld ob. Blood. 2025 Apr 17;145(16):1802-1813. doi: 10.1182/blood.2024025500. Blood. 2025. PMID: 39792929
Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation.
Champagne J, Nielsen MM, Feng X, Montenegro Navarro J, Pataskar A, Voogd R, Giebel L, Nagel R, Berenst N, Fumagalli A, Kochavi A, Lovecchio D, Valcanover L, Malka Y, Yang W, Laos M, Li Y, Proost N, van de Ven M, van Tellingen O, Bleijerveld OB, Haanen JBAG, Olweus J, Agami R. Champagne J, et al. Among authors: bleijerveld ob. Immunity. 2025 Jan 14;58(1):247-262.e9. doi: 10.1016/j.immuni.2024.12.004. Epub 2025 Jan 3. Immunity. 2025. PMID: 39755122 Free article.
An antibiotic that mediates immune destruction of senescent cancer cells.
Casagrande Raffi G, Chen J, Feng X, Chen Z, Lieftink C, Deng S, Mo J, Zeng C, Steur M, Wang J, Bleijerveld OB, Hoekman L, van der Wel N, Wang F, Beijersbergen R, Zheng J, Bernards R, Wang L. Casagrande Raffi G, et al. Among authors: bleijerveld ob. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2417724121. doi: 10.1073/pnas.2417724121. Epub 2024 Dec 18. Proc Natl Acad Sci U S A. 2024. PMID: 39693343 Free PMC article.
TMED inhibition suppresses cell surface PD-1 expression and overcomes T cell dysfunction.
Vredevoogd DW, Apriamashvili G, Levy PL, Sinha S, Huinen ZR, Visser NL, de Bruijn B, Boshuizen J, van Hal-van Veen SE, Ligtenberg MA, Bleijerveld OB, Lin CP, Díaz-Gómez J, Sánchez SD, Markovits E, Simon Nieto J, van Vliet A, Krijgsman O, Markel G, Besser MJ, Altelaar M, Ruppin E, Peeper DS. Vredevoogd DW, et al. Among authors: bleijerveld ob. J Immunother Cancer. 2024 Nov 7;12(11):e010145. doi: 10.1136/jitc-2024-010145. J Immunother Cancer. 2024. PMID: 39510795 Free PMC article.
UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168.
Yalçin Z, Lam SY, Peuscher MH, van der Torre J, Zhu S, Iyengar PV, Salas-Lloret D, de Krijger I, Moatti N, van der Lugt R, Falcone M, Cerutti A, Bleijerveld OB, Hoekman L, González-Prieto R, Jacobs JJL. Yalçin Z, et al. Among authors: bleijerveld ob. Nat Commun. 2024 Jun 12;15(1):5032. doi: 10.1038/s41467-024-49431-6. Nat Commun. 2024. PMID: 38866770 Free PMC article.
50 results