Lin CC - Search Results

1

The C-terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2.

Zingg D, Lin CC, Yemelyanenko J, Wieteska L, Kas SM, Bleijerveld OB, Chao X, Bhin J, Lutz C, Wientjens E, Klarenbeek S, Zanetti G, Annunziato S, Siteur B, van der Burg E, Drenth AP, van de Ven M, Wessels LFA, Altelaar M, Ladbury JE, Jonkers J. Zingg D, et al. Among authors: lin cc. Cancer Res. 2025 Jun 24. doi: 10.1158/0008-5472.CAN-24-3349. Online ahead of print. Cancer Res. 2025. PMID: 40554806

2

The combined action of the intracellular regions regulates FGFR2 kinase activity.

Lin CC, Wieteska L, Poncet-Montange G, Suen KM, Arold ST, Ahmed Z, Ladbury JE. Lin CC, et al. Commun Biol. 2023 Jul 14;6(1):728. doi: 10.1038/s42003-023-05112-6. Commun Biol. 2023. PMID: 37452126 Free PMC article.

3

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.

Lin CC, Suen KM, Stainthorp A, Wieteska L, Biggs GS, Leitão A, Montanari CA, Ladbury JE. Lin CC, et al. Cancer Lett. 2019 Aug 10;457:86-97. doi: 10.1016/j.canlet.2019.05.008. Epub 2019 May 14. Cancer Lett. 2019. PMID: 31100409 Free PMC article.

4

Grb2 binding induces phosphorylation-independent activation of Shp2.

Lin CC, Wieteska L, Suen KM, Kalverda AP, Ahmed Z, Ladbury JE. Lin CC, et al. Commun Biol. 2021 Apr 1;4(1):437. doi: 10.1038/s42003-021-01969-7. Commun Biol. 2021. PMID: 33795832 Free PMC article.

5

Phase separation enhances probability of receptor signalling and drug targeting.

Ladbury JE, Lin CC, Suen KM. Ladbury JE, et al. Among authors: lin cc. Trends Biochem Sci. 2023 May;48(5):428-436. doi: 10.1016/j.tibs.2023.01.005. Epub 2023 Feb 7. Trends Biochem Sci. 2023. PMID: 36759237 Free article. Review.

6

The emerging role of receptor tyrosine kinase phase separation in cancer.

Lin CC, Suen KM, Lidster J, Ladbury JE. Lin CC, et al. Trends Cell Biol. 2024 May;34(5):371-379. doi: 10.1016/j.tcb.2023.09.002. Epub 2023 Sep 28. Trends Cell Biol. 2024. PMID: 37777392 Free article. Review.

7

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.

Ahmed Z, Lin CC, Suen KM, Melo FA, Levitt JA, Suhling K, Ladbury JE. Ahmed Z, et al. Among authors: lin cc. J Cell Biol. 2013 Feb 18;200(4):493-504. doi: 10.1083/jcb.201204106. J Cell Biol. 2013. PMID: 23420874 Free PMC article.

8

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.

Ahmed Z, George R, Lin CC, Suen KM, Levitt JA, Suhling K, Ladbury JE. Ahmed Z, et al. Among authors: lin cc. Cell Signal. 2010 Jan;22(1):23-33. doi: 10.1016/j.cellsig.2009.08.011. Epub 2009 Sep 6. Cell Signal. 2010. PMID: 19735729

9

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.

Suen KM, Lin CC, George R, Melo FA, Biggs ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE. Suen KM, et al. Among authors: lin cc. Nat Struct Mol Biol. 2013 May;20(5):620-7. doi: 10.1038/nsmb.2557. Epub 2013 Apr 14. Nat Struct Mol Biol. 2013. PMID: 23584453 Free PMC article.

10

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state.

Lin CC, Suen KM, Jeffrey PA, Wieteska L, Lidster JA, Bao P, Curd AP, Stainthorp A, Seiler C, Koss H, Miska E, Ahmed Z, Evans SD, Molina-París C, Ladbury JE. Lin CC, et al. Mol Cell. 2022 Mar 17;82(6):1089-1106.e12. doi: 10.1016/j.molcel.2022.02.005. Epub 2022 Feb 28. Mol Cell. 2022. PMID: 35231400 Free PMC article.

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