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Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease.
Wu KM, Xu QH, Liu YQ, Feng YW, Han SD, Zhang YR, Chen SD, Guo Y, Wu BS, Ma LZ, Zhang Y, Chen YL, Yang L, Yang ZF, Xiao YJ, Wang TT, Zhao J, Chen SF, Cui M, Lu BX, Le WD, Shu YS, Ye K, Li JY, Li WS, Wang J, Liu C, Yuan P, Yu JT. Wu KM, et al. Among authors: shu ys. Science. 2025 Feb 21;387(6736):892-900. doi: 10.1126/science.adp3645. Epub 2025 Feb 20. Science. 2025. PMID: 39977508
SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.
Jiang TX, Zou JB, Zhu QQ, Liu CH, Wang GF, Du TT, Luo ZY, Guo F, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa SI, Goldberg AL, Qiu XB. Jiang TX, et al. Among authors: shu ys. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13404-13413. doi: 10.1073/pnas.1901039116. Epub 2019 Jun 18. Proc Natl Acad Sci U S A. 2019. PMID: 31213539 Free PMC article.
36 results