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Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity.
Eyunni S, Mannan R, Zhang Y, Young E, Zhang Q, Luo J, Pang M, Mahapatra S, Tien JC, George JM, Jaber M, Hakkani H, Carson SE, Todd AJ, Hosseini N, Gondal M, Rebernick RJ, Cao X, Su F, Wang R, Mehra R, Li J, Cieslik M, Chinnaiyan AM, Parolia A. Eyunni S, et al. Among authors: todd aj. Science. 2025 Jun 26:eadv2367. doi: 10.1126/science.adv2367. Online ahead of print. Science. 2025. PMID: 40570057
Defining CDK12 as a tumor suppressor and therapeutic target in mouse models of tubo-ovarian high-grade serous carcinoma.
Tien JC, Zhai Y, Wu R, Zhang Y, Chang Y, Cheng Y, Todd AJ, Wheeler CE, Li S, Mannan R, Cheng C, Magnuson B, Cruz G, Cao Y, Mahapatra S, Stolfi C, Cao X, Su F, Wang R, Yang J, Zhou L, Qiao Y, Xiao L, Cieslik M, Wang X, Wang Z, Chou J, Fearon ER, Ding K, Cho KR, Chinnaiyan AM. Tien JC, et al. Among authors: todd aj. Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2426909122. doi: 10.1073/pnas.2426909122. Epub 2025 Jun 12. Proc Natl Acad Sci U S A. 2025. PMID: 40504161 Free PMC article.
Single-neuron projectome reveals organization of somatosensory ascending pathways in the mouse brain.
Ding WQ, Song W, Shi X, Feng Z, Chen X, Xie T, Liu Y, Zhou J, Chen Y, Lin JK, Wang QM, Zhou H, Liang TY, Jiang T, Ren B, Yao H, Li YQ, Evrard HC, Poo MM, Li H, Li X, Gong H, Todd AJ, Li A, Wang X, Deng J, Sun YG. Ding WQ, et al. Among authors: todd aj. Neuron. 2025 Apr 8:S0896-6273(25)00179-5. doi: 10.1016/j.neuron.2025.03.007. Online ahead of print. Neuron. 2025. PMID: 40209714
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13.
Tien JC, Luo J, Chang Y, Zhang Y, Cheng Y, Wang X, Yang J, Mannan R, Mahapatra S, Shah P, Wang XM, Todd AJ, Eyunni S, Cheng C, Rebernick RJ, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt SJ, Cao X, Miner SJ, Zhou L, Wu YM, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson DR, Wang Z, Feng FY, Chou J, Lord CJ, Ding K, Chinnaiyan AM. Tien JC, et al. Among authors: todd aj. Cell Rep Med. 2024 Oct 15;5(10):101758. doi: 10.1016/j.xcrm.2024.101758. Epub 2024 Oct 4. Cell Rep Med. 2024. PMID: 39368479 Free PMC article.
Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons.
Bell AM, Utting C, Dickie AC, Kucharczyk MW, Quillet R, Gutierrez-Mecinas M, Razlan ANB, Cooper AH, Lan Y, Hachisuka J, Weir GA, Bannister K, Watanabe M, Kania A, Hoon MA, Macaulay IC, Denk F, Todd AJ. Bell AM, et al. Among authors: todd aj. Proc Natl Acad Sci U S A. 2024 Jun 4;121(23):e2314213121. doi: 10.1073/pnas.2314213121. Epub 2024 May 28. Proc Natl Acad Sci U S A. 2024. PMID: 38805282 Free PMC article.
CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality.
Tien JC, Chang Y, Zhang Y, Chou J, Cheng Y, Wang X, Yang J, Mannan R, Shah P, Wang XM, Todd AJ, Eyunni S, Cheng C, Rebernick RJ, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt SJ, Cao X, Miner SJ, Zhou L, Wu YM, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson DR, Wang Z, Feng FY, Lord CJ, Ding K, Chinnaiyan AM. Tien JC, et al. Among authors: todd aj. bioRxiv [Preprint]. 2024 Mar 21:2024.03.20.585990. doi: 10.1101/2024.03.20.585990. bioRxiv. 2024. Update in: Cell Rep Med. 2024 Oct 15;5(10):101758. doi: 10.1016/j.xcrm.2024.101758. PMID: 38562774 Free PMC article. Updated. Preprint.
Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons.
Bell AM, Utting C, Dickie AC, Kucharczyk MW, Quillet R, Gutierrez-Mecinas M, Razlan ANB, Cooper AH, Lan Y, Hachisuka J, Weir GA, Bannister K, Watanabe M, Kania A, Hoon MA, Macaulay IC, Denk F, Todd AJ. Bell AM, et al. Among authors: todd aj. bioRxiv [Preprint]. 2023 Sep 2:2023.08.20.553715. doi: 10.1101/2023.08.20.553715. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 Jun 4;121(23):e2314213121. doi: 10.1073/pnas.2314213121. PMID: 37786726 Free PMC article. Updated. Preprint.
167 results