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355 results

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Page 1
Ipatasertib in Patients with Tumors with AKT Mutations: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Sub-protocol Z1K.
McCourt CK, Wei Z, Kalinsky K, Gray R, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Force J, Pakanati A, Tricoli JV, Conley BA, Arteaga C, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT. McCourt CK, et al. Among authors: chen ap. Clin Cancer Res. 2025 Jun 27. doi: 10.1158/1078-0432.CCR-24-3431. Online ahead of print. Clin Cancer Res. 2025. PMID: 40577532
Consensus recommendations for hyperpolarized [1-13C]pyruvate MRI multi-center human studies.
Punwani S, Larson PEZ, Laustsen C, VanderMeulen J, Ardenkjær-Larsen JH, Autry AW, Bankson JA, Bernard J, Bok R, Bertelsen LB, Che J, Chen AP, Chowdhury R, Comment A, Cunningham CH, Dang D, Gallagher FA, Gaunt A, Gong Y, Gordon JW, Grimmer A, Grist J, Hansen ESS, Lerche MH, Hesketh RL, Hoevener JB, Hsieh CY, Keshari KR, Kozerke S, Lanz T, Mayer D, McLean M, Park JM, Slater J, Tyler D, Vanderheyden JL, von Morze C, Zaccagna F, Zaha V, Xu D, Vigneron D; HP 13C MRI Consensus Group. Punwani S, et al. Among authors: chen ap. Magn Reson Med. 2025 Jun 16. doi: 10.1002/mrm.30570. Online ahead of print. Magn Reson Med. 2025. PMID: 40523079
Efficacy and safety of selumetinib in adults with neurofibromatosis type 1 and symptomatic, inoperable plexiform neurofibromas (KOMET): a multicentre, international, randomised, placebo-controlled, parallel, double-blind, phase 3 study.
Chen AP, Coyne GO, Wolters PL, Martin S, Farschtschi S, Blanco I, Chen Z, Darrigo LG Jr, Eoli M, Whittle JR, Nishida Y, Lamarca R, de la Rosa Rodriguez R, Adeyemi A, Herrero I, Llorente N, Diede SJ, Dombi E, Wolkenstein P; KOMET study investigators. Chen AP, et al. Lancet. 2025 Jun 21;405(10496):2217-2230. doi: 10.1016/S0140-6736(25)00986-9. Epub 2025 Jun 2. Lancet. 2025. PMID: 40473450 Clinical Trial.
A Concordance Study Among 26 NGS Laboratories Participating in the National Cancer Institute-Molecular Analysis for Therapy Choice (NCI-MATCH) Clinical Trial.
Zane LK, Yee LM, Chang TC, Sklar J, Yang G, Wen JD, Li P, Harrington R, Sims DJ, Harper K, Trent JM, LoBello JR, Szelinger S, Benson K, Zeng J, Poorman K, Xu D, Frampton GM, Pavlick DC, Miller VA, Tandon B, Swat W, Weiss L, Funari VA, Conroy JM, Prescott JL, Chandra PK, Ma C, Champion KJ, Baschkopf GX, Fesko YA, Freitas TAK, Tomlins SA, Hovelson DH, White K, Sorrells S, Tell R, Beaubier N, King D, Li L, Kelly K, Uvalic J, Meyers B, Kolhe R, Lindeman NI, Baltay M, Sholl LM, Lopategui J, Vail E, Zhang W, Telatar M, Afkhami M, Hsiao SJ, Mansukhani MM, Adams E, Jiang L, Aldape KD, Raffeld M, Xi L, Stehr H, Segal JP, Aisner DL, Davies KD, Brown NA, Livingston RJ, Konnick EQ, Song W, Solomon JP, Walther Z, McShane LM, Harris LN, Chen AP, Tsongalis GJ, Hamilton SR, Flaherty KT, O'Dwyer PJ, Conley BA, Patton DR, Iafrate AJ, Williams PM, Tricoli JV, Karlovich C. Zane LK, et al. Among authors: chen ap. Clin Cancer Res. 2025 Jun 4. doi: 10.1158/1078-0432.CCR-24-2188. Online ahead of print. Clin Cancer Res. 2025. PMID: 40465838
Preclinical NCI-MPACT: prospective modeling of the mutation-based NCI-MPACT clinical trial therapeutic strategy in patient-derived xenograft models.
Evrard YA, Alcoser SY, Mullendore M, Chen L, Lih CJ, Kannan VR, Datta V, Dutko L, Jiwani S, Rubinstein LV, Zhao Y, Williams PM, Palmisano A, Kuhlmann L, Simpson M, Kummar S, Das B, Karlovich C, Polley E, Li MC, Chen AP, Hollingshead MG, Doroshow JH. Evrard YA, et al. Among authors: chen ap. Front Oncol. 2025 May 19;15:1571635. doi: 10.3389/fonc.2025.1571635. eCollection 2025. Front Oncol. 2025. PMID: 40458731 Free PMC article.
Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas.
O'Sullivan Coyne G, Kummar S, Rubinstein LV, Wilsker D, Moore N, Hogu M, Piekarz R, Covey J, Beumer JH, Ferry-Galow KV, Villaruz LC, Hollingshead MG, Holleran JL, Deppas JJ, Pommier Y, Ko B, Johnson BC, Parchhment RE, Ivy P, Doroshow JH, Chen AP. O'Sullivan Coyne G, et al. Among authors: chen ap. Cancer Chemother Pharmacol. 2025 May 29;95(1):58. doi: 10.1007/s00280-025-04778-5. Cancer Chemother Pharmacol. 2025. PMID: 40439882 Free PMC article. Clinical Trial.
Concordance between tumor tissue and plasma DNA genotyping in the NCI-MATCH trial (EAY131).
Gouda MA, Janku F, Yuan Y, Drusbosky LM, Chen AP, Zheng X, Patel K, Hamilton SR, Routbort M, Tricoli JV, Williams PM, Iafrate AJ, Sklar J, Coffey B, Little RF, Arteaga CL, O'Dwyer PJ, Flaherty KT, Harris LN, Meric-Bernstam F. Gouda MA, et al. Among authors: chen ap. Clin Cancer Res. 2025 May 19. doi: 10.1158/1078-0432.CCR-24-3531. Online ahead of print. Clin Cancer Res. 2025. PMID: 40388547
Consensus Recommendations for Hyperpolarized [1-13C]pyruvate MRI Multi-center Human Studies.
Punwani S, Larson PE, Laustsen C, VanderMeulen J, Ardenkjær-Larsen JH, Autry AW, Bankson JA, Bernard J, Bok R, Bertelsen LB, Che J, Chen AP, Chowdhury R, Comment A, Cunningham CH, Dang D, Gallagher FA, Gaunt A, Gong Y, Gordon JW, Grimmer A, Grist J, Hansen ESS, Lerche MH, Hesketh RL, Hoevener JB, Hsieh CY, Keshari KR, Kozerke S, Lanz T, Mayer D, McLean M, Park JM, Slater J, Tyler D, Vanderheyden JL, von Morze C, Zaccagna F, Zaha V, Xu D, Vigneron D; HP 13C MRI Consensus Group. Punwani S, et al. Among authors: chen ap. ArXiv [Preprint]. 2025 Apr 29:arXiv:2504.20440v1. ArXiv. 2025. Update in: Magn Reson Med. 2025 Jun 16. doi: 10.1002/mrm.30570. PMID: 40342865 Free PMC article. Updated. Preprint.
355 results