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428 results

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Page 1
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants.
Revach OY, Cicerchia AM, Shorer O, Palin CA, Petrova B, Anderson S, Liu B, Park J, Chen L, Mehta A, Wright SJ, McNamee N, Tal-Mason A, Cattaneo G, Tiwari P, Xie H, Sweere JM, Cheng LC, Sigal N, Enrico E, Miljkovic M, Evans SA, Nguyen N, Whidden ME, Srinivasan R, Spitzer MH, Sun Y, Sharova T, Lawless AR, Michaud WA, Rasmussen MQ, Fang J, Brook JR, Chen F, Wang X, Ferrone CR, Lawrence DP, Sullivan RJ, Liu D, Sachdeva UM, Sen DR, Flaherty KT, Manguso RT, Bod L, Kellis M, Boland GM, Yizhak K, Yang J, Kanarek N, Sade-Feldman M, Hacohen N, Jenkins RW. Revach OY, et al. Among authors: flaherty kt. Cell Rep Med. 2025 Jun 19:102210. doi: 10.1016/j.xcrm.2025.102210. Online ahead of print. Cell Rep Med. 2025. PMID: 40578364 Free article.
Ipatasertib in Patients with Tumors with AKT Mutations: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Sub-protocol Z1K.
McCourt CK, Wei Z, Kalinsky K, Gray R, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Force J, Pakanati A, Tricoli JV, Conley BA, Arteaga C, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT. McCourt CK, et al. Among authors: flaherty kt. Clin Cancer Res. 2025 Jun 27. doi: 10.1158/1078-0432.CCR-24-3431. Online ahead of print. Clin Cancer Res. 2025. PMID: 40577532
The Rise of New Targets in Melanoma.
Bai X, Flaherty KT. Bai X, et al. Among authors: flaherty kt. Br J Dermatol. 2025 Jun 26:ljaf251. doi: 10.1093/bjd/ljaf251. Online ahead of print. Br J Dermatol. 2025. PMID: 40570019
Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma.
Monson KR, Ferguson R, Handzlik JE, Morales L, Xiong J, Chat V, Dagayev S, Khodadadi-Jamayran A, Simpson D, Kazlow E, Bunis A, Sreenivasaiah C, Ibrahim M, Voloshyna I, Ouwerkerk W, Luiten RM, Capone M, Madonna G, Lu Y, Shao Y, Pavlick A, Krogsgaard M, Mehnert J, Tang H, Dolfi S, Tenney D, Haanen JBAG, Gajewski TF, Hodi FS, Flaherty KT, Couts K, Robinson W, Puzanov I, Ernstoff MS, Rahma O, Postow M, Sullivan RJ, Luke JJ, Ascierto PA; IO-GEM Consortium; Osman I, Kirchhoff T. Monson KR, et al. Among authors: flaherty kt. Nat Med. 2025 Jun 5. doi: 10.1038/s41591-025-03699-3. Online ahead of print. Nat Med. 2025. PMID: 40473950
A Concordance Study Among 26 NGS Laboratories Participating in the National Cancer Institute-Molecular Analysis for Therapy Choice (NCI-MATCH) Clinical Trial.
Zane LK, Yee LM, Chang TC, Sklar J, Yang G, Wen JD, Li P, Harrington R, Sims DJ, Harper K, Trent JM, LoBello JR, Szelinger S, Benson K, Zeng J, Poorman K, Xu D, Frampton GM, Pavlick DC, Miller VA, Tandon B, Swat W, Weiss L, Funari VA, Conroy JM, Prescott JL, Chandra PK, Ma C, Champion KJ, Baschkopf GX, Fesko YA, Freitas TAK, Tomlins SA, Hovelson DH, White K, Sorrells S, Tell R, Beaubier N, King D, Li L, Kelly K, Uvalic J, Meyers B, Kolhe R, Lindeman NI, Baltay M, Sholl LM, Lopategui J, Vail E, Zhang W, Telatar M, Afkhami M, Hsiao SJ, Mansukhani MM, Adams E, Jiang L, Aldape KD, Raffeld M, Xi L, Stehr H, Segal JP, Aisner DL, Davies KD, Brown NA, Livingston RJ, Konnick EQ, Song W, Solomon JP, Walther Z, McShane LM, Harris LN, Chen AP, Tsongalis GJ, Hamilton SR, Flaherty KT, O'Dwyer PJ, Conley BA, Patton DR, Iafrate AJ, Williams PM, Tricoli JV, Karlovich C. Zane LK, et al. Among authors: flaherty kt. Clin Cancer Res. 2025 Jun 4. doi: 10.1158/1078-0432.CCR-24-2188. Online ahead of print. Clin Cancer Res. 2025. PMID: 40465838
Facts & Hopes: towards the next quantum leap in melanoma.
Flaherty KT, Aplin AE, Davies MA, Hacohen N, Herlyn M, Hoon D, Hwu P, Lotem M, Mulé J, Wargo JA, Fisher DE. Flaherty KT, et al. Clin Cancer Res. 2025 May 23. doi: 10.1158/1078-0432.CCR-25-0278. Online ahead of print. Clin Cancer Res. 2025. PMID: 40407722
Concordance between tumor tissue and plasma DNA genotyping in the NCI-MATCH trial (EAY131).
Gouda MA, Janku F, Yuan Y, Drusbosky LM, Chen AP, Zheng X, Patel K, Hamilton SR, Routbort M, Tricoli JV, Williams PM, Iafrate AJ, Sklar J, Coffey B, Little RF, Arteaga CL, O'Dwyer PJ, Flaherty KT, Harris LN, Meric-Bernstam F. Gouda MA, et al. Among authors: flaherty kt. Clin Cancer Res. 2025 May 19. doi: 10.1158/1078-0432.CCR-24-3531. Online ahead of print. Clin Cancer Res. 2025. PMID: 40388547
Phase II Study of Copanlisib in Patients With PTEN Loss: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols Z1G and Z1H.
Gouda MA, Wei Z, Rodon J, Davies MA, Janku F, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Liu R, Bota DA, Swiecicki PL, Buchschacher GL, Tricoli JV, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT. Gouda MA, et al. Among authors: flaherty kt. JCO Precis Oncol. 2025 Feb;9:e2400451. doi: 10.1200/PO-24-00451. Epub 2025 Feb 6. JCO Precis Oncol. 2025. PMID: 39913886 Clinical Trial.
A plain language summary of the 7-year update from part 1 of the COLUMBUS study: encorafenib and binimetinib for people with BRAF V600-mutant melanoma.
Schadendorf D, Dummer R, Flaherty KT, Robert C, Arance A, de Groot JWB, Garbe C, Gogas HJ, Gutzmer R, Krajsová I, Liszkay L, Loquai C, Mandalà M, Yamazaki N, Queirolo P, Guenzel C, Polli A, Thakur M, di Pietro A, Ascierto PA. Schadendorf D, et al. Among authors: flaherty kt. Future Oncol. 2025 Feb;21(5):523-531. doi: 10.1080/14796694.2024.2442851. Epub 2025 Jan 14. Future Oncol. 2025. PMID: 39810544 Free PMC article.
428 results