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NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis.
Tong Y, Lear TB, Tuncer F, Villandre JJ, Boudreau ÁN, Lin B, Alfaras I, Kennerdell JR, Camarco DP, Larsen MB, Hua Y, Chen Y, Chandler ME, Pineda R, Barratt-Boyes SM, Evankovich JW, Finkel T, Liu Y, Chen BB. Tong Y, et al. Among authors: alfaras i. Adv Sci (Weinh). 2025 Jun 27:e00798. doi: 10.1002/advs.202500798. Online ahead of print. Adv Sci (Weinh). 2025. PMID: 40577599
Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection.
Lear TB, Larsen MB, Lin B, Treat BR, Cao Q, Boudreau ÁN, Lockwood KC, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Tong Y, Ma J, Liu J, Tan JX, Tuncer F, Villandre JJ, Hertzel L, Myerburg MM, Chen Y, St Croix C, Sekine Y, Evankovich JW, Barratt-Boyes SM, Finkel T, Chen BB, Liu Y. Lear TB, et al. Among authors: alfaras i. Sci Adv. 2025 Jun 6;11(23):eadv4033. doi: 10.1126/sciadv.adv4033. Epub 2025 Jun 4. Sci Adv. 2025. PMID: 40465712 Free PMC article.
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.
Winicki NM, Nanavati AP, Morrell CH, Moen JM, Axsom JE, Krawczyk M, Petrashevskaya NN, Beyman MG, Ramirez C, Alfaras I, Mitchell SJ, Juhaszova M, Riordon DR, Wang M, Zhang J, Cerami A, Brines M, Sollott SJ, de Cabo R, Lakatta EG. Winicki NM, et al. Among authors: alfaras i. Front Cardiovasc Med. 2023 Jan 18;9:1096887. doi: 10.3389/fcvm.2022.1096887. eCollection 2022. Front Cardiovasc Med. 2023. PMID: 36741836 Free PMC article.
Modulation of lysosomal function as a therapeutic approach for coronaviral infections.
Liu Y, Lear T, Larsen M, Lin B, Cao Q, Alfaras I, Kennerdell J, Salminen L, Camarco D, Lockwood K, Ma J, Liu J, Tan J, Myerburg M, Chen Y, St Croix C, Sekine Y, Evankovich J, Finkel T, Chen B. Liu Y, et al. Among authors: alfaras i. Res Sq [Preprint]. 2021 Apr 23:rs.3.rs-419305. doi: 10.21203/rs.3.rs-419305/v1. Res Sq. 2021. PMID: 34013250 Free PMC article. Preprint.
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan.
Aon MA, Cortassa S, Juhaszova M, González-Reyes JA, Calvo-Rubio M, Villalba JM, Lachance AD, Ziman BD, Mitchell SJ, Murt KN, Axsom JEC, Alfaras I, Britton SL, Koch LG, de Cabo R, Lakatta EG, Sollott SJ. Aon MA, et al. Among authors: alfaras i. NPJ Aging Mech Dis. 2021 Jan 4;7(1):1. doi: 10.1038/s41514-020-00054-3. NPJ Aging Mech Dis. 2021. PMID: 33398019 Free PMC article.
Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques.
Palliyaguru DL, Vieira Ligo Teixeira C, Duregon E, di Germanio C, Alfaras I, Mitchell SJ, Navas-Enamorado I, Shiroma EJ, Studenski S, Bernier M, Camandola S, Price NL, Ferrucci L, de Cabo R. Palliyaguru DL, et al. Among authors: alfaras i. J Gerontol A Biol Sci Med Sci. 2021 Mar 31;76(4):552-560. doi: 10.1093/gerona/glaa285. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33211821 Free PMC article.
A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry.
Chen Y, Lear TB, Evankovich JW, Larsen MB, Lin B, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Lockwood KC, Liu J, Myerburg MM, McDyer JF, Liu Y, Finkel T, Chen BB. Chen Y, et al. Among authors: alfaras i. Res Sq [Preprint]. 2020 Aug 14:rs.3.rs-48659. doi: 10.21203/rs.3.rs-48659/v1. Res Sq. 2020. Update in: Nat Commun. 2021 Jun 23;12(1):3907. doi: 10.1038/s41467-021-24156-y. PMID: 32818215 Free PMC article. Updated. Preprint.
22 results