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NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis.
Tong Y, Lear TB, Tuncer F, Villandre JJ, Boudreau ÁN, Lin B, Alfaras I, Kennerdell JR, Camarco DP, Larsen MB, Hua Y, Chen Y, Chandler ME, Pineda R, Barratt-Boyes SM, Evankovich JW, Finkel T, Liu Y, Chen BB. Tong Y, et al. Among authors: finkel t. Adv Sci (Weinh). 2025 Jun 27:e00798. doi: 10.1002/advs.202500798. Online ahead of print. Adv Sci (Weinh). 2025. PMID: 40577599
Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection.
Lear TB, Larsen MB, Lin B, Treat BR, Cao Q, Boudreau ÁN, Lockwood KC, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Tong Y, Ma J, Liu J, Tan JX, Tuncer F, Villandre JJ, Hertzel L, Myerburg MM, Chen Y, St Croix C, Sekine Y, Evankovich JW, Barratt-Boyes SM, Finkel T, Chen BB, Liu Y. Lear TB, et al. Among authors: finkel t. Sci Adv. 2025 Jun 6;11(23):eadv4033. doi: 10.1126/sciadv.adv4033. Epub 2025 Jun 4. Sci Adv. 2025. PMID: 40465712 Free PMC article.
Insights from the Biorepository and Integrative Genomics pediatric resource.
Buonaiuto S, Marsico F, Mohammed A, Chinthala LK, Amos-Abanyie EK; Regeneron Genetics Center; Prins P, Mozhui K, Rooney RJ, Williams RW, Davis RL, Finkel TH, Brown CW, Colonna V. Buonaiuto S, et al. Among authors: finkel th. Nat Commun. 2025 May 22;16(1):4750. doi: 10.1038/s41467-025-59375-0. Nat Commun. 2025. PMID: 40404628 Free PMC article.
Data-driven consideration of genetic disorders for global genomic newborn screening programs.
Minten T, Bick S, Adelson S, Gehlenborg N, Amendola LM, Boemer F, Coffey AJ, Encina N, Ferlini A, Kirschner J, Russell BE, Servais L, Sund KL, Taft RJ, Tsipouras P, Zouk H; ICoNS Gene List Contributors; Bick D; International Consortium on Newborn Sequencing (ICoNS); Green RC, Gold NB. Minten T, et al. Genet Med. 2025 May 9;27(7):101443. doi: 10.1016/j.gim.2025.101443. Online ahead of print. Genet Med. 2025. PMID: 40357684
Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner.
Hernández-Arciga U, Stamenkovic C, Yadav S, Nicoletti C, Albalawy WN, Al Hammood F, Gonzalez TF, Naikwadi MU, Graham A, Smarz C, Little GJ, Williams SG, McMahon B, Sipula IJ, Vandevender AM, Chuan B, Cooke D, Pinto AFM, Flores LC, Hartman HL, Diedrich JK, Brooke RT, Alder JK, Frahm KA, Pascal LE, Stolt E, Troensegaard H, Øvrebø B, Elshorbagy A, Molina E, Vinknes KJ, Tan RJ, Weisz OA, Bueno M, Eickelberg O, Steinhauser ML, Finkel T, Ables GP, Ikeno Y, Olsen T, Sacco A, Jurczak MJ, Sukoff Rizzo SJ, Parkhitko AA. Hernández-Arciga U, et al. Among authors: finkel t. Sci Adv. 2025 Apr 18;11(16):eads1532. doi: 10.1126/sciadv.ads1532. Epub 2025 Apr 16. Sci Adv. 2025. PMID: 40238871 Free PMC article.
ATP depletion in anthrax edema toxin pathogenesis.
Liu J, Cao Q, Ewing M, Zuo Z, Kennerdell JR, Finkel T, Leppla SH, Liu S. Liu J, et al. Among authors: finkel t. PLoS Pathog. 2025 Apr 1;21(4):e1013017. doi: 10.1371/journal.ppat.1013017. eCollection 2025 Apr. PLoS Pathog. 2025. PMID: 40168442 Free PMC article.
Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuli.
Marmisolle I, Chacón E, Mansilla S, Ruiz S, Bresque M, Martínez J, Martínez-Zamudio RI, Herbig U, Liu J, Finkel T, Escande C, Castro L, Quijano C. Marmisolle I, et al. Among authors: finkel t. Redox Biol. 2025 May;82:103606. doi: 10.1016/j.redox.2025.103606. Epub 2025 Mar 22. Redox Biol. 2025. PMID: 40158257 Free PMC article.
Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation.
Garcia GL, Orellana T, Gorecki G, Frisbie L, Baruwal R, Suresh S, Goldfeld E, Beddows I, MacFawn IP, Britt AK, Hale MM, Elhaw AT, Isett BR, Hempel N, Bao R, Shen H, Buckanovich RJ, Finkel T, Drapkin R, Soong TR, Bruno TC, Atiya HI, Coffman LG. Garcia GL, et al. Among authors: finkel t. Cancer Discov. 2025 Jun 3;15(6):1203-1224. doi: 10.1158/2159-8290.CD-24-0805. Cancer Discov. 2025. PMID: 40084985 Free PMC article.
Regulation of lung progenitor plasticity and repair by fatty acid oxidation.
Angeles-Lopez QD, Rodriguez-Lopez J, Agudelo Garcia P, Calyeca J, Álvarez D, Bueno M, Tu LN, Salazar-Terreros M, Vanegas-Avendaño N, Krull JE, Moldobaeva A, Bogamuwa S, Scott SS, Peters V, Reader BF, Shiva S, Jurczak M, Ghaedi M, Ma Q, Finkel T, Rojas M, Mora AL. Angeles-Lopez QD, et al. Among authors: finkel t. JCI Insight. 2025 Feb 10;10(3):e165837. doi: 10.1172/jci.insight.165837. JCI Insight. 2025. PMID: 39927460 Free PMC article.
376 results