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NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis.
Tong Y, Lear TB, Tuncer F, Villandre JJ, Boudreau ÁN, Lin B, Alfaras I, Kennerdell JR, Camarco DP, Larsen MB, Hua Y, Chen Y, Chandler ME, Pineda R, Barratt-Boyes SM, Evankovich JW, Finkel T, Liu Y, Chen BB. Tong Y, et al. Among authors: lear tb. Adv Sci (Weinh). 2025 Jun 27:e00798. doi: 10.1002/advs.202500798. Online ahead of print. Adv Sci (Weinh). 2025. PMID: 40577599
Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection.
Lear TB, Larsen MB, Lin B, Treat BR, Cao Q, Boudreau ÁN, Lockwood KC, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Tong Y, Ma J, Liu J, Tan JX, Tuncer F, Villandre JJ, Hertzel L, Myerburg MM, Chen Y, St Croix C, Sekine Y, Evankovich JW, Barratt-Boyes SM, Finkel T, Chen BB, Liu Y. Lear TB, et al. Sci Adv. 2025 Jun 6;11(23):eadv4033. doi: 10.1126/sciadv.adv4033. Epub 2025 Jun 4. Sci Adv. 2025. PMID: 40465712 Free PMC article.
KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation.
Lockwood KC, Lear TB, Rajbhandari S, McKelvey AC, Dunn SR, Boudreau ÁN, Liu Y, Chen BB. Lockwood KC, et al. Among authors: lear tb. FEBS J. 2023 Aug;290(15):3802-3811. doi: 10.1111/febs.16780. Epub 2023 Apr 7. FEBS J. 2023. PMID: 36938956 Free PMC article.
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O'Donnell CP, Finkel T, Chen BB, Mallampalli RK. Liu Y, et al. Among authors: lear tb. Nat Chem Biol. 2021 Mar;17(3):298-306. doi: 10.1038/s41589-020-00723-0. Epub 2021 Jan 25. Nat Chem Biol. 2021. PMID: 33495648 Free PMC article.
A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry.
Chen Y, Lear TB, Evankovich JW, Larsen MB, Lin B, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Lockwood KC, Liu J, Myerburg MM, McDyer JF, Liu Y, Finkel T, Chen BB. Chen Y, et al. Among authors: lear tb. Res Sq [Preprint]. 2020 Aug 14:rs.3.rs-48659. doi: 10.21203/rs.3.rs-48659/v1. Res Sq. 2020. Update in: Nat Commun. 2021 Jun 23;12(1):3907. doi: 10.1038/s41467-021-24156-y. PMID: 32818215 Free PMC article. Updated. Preprint.
18 results