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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis.
Qian J, Ma C, Waterbury QT, Zhi X, Moon CS, Tu R, Kobayashi H, Wu F, Zheng B, Zeng Y, Zheng H, Ochiai Y, White RA, Harle DW, LaBella JS, Zamechek LB, ZhongMing Hu L, Moy RH, Han AS, Daugherty BL, Lederman S, Wang TC. Qian J, et al. Among authors: harle dw. Cancer Cell. 2025 Jun 21:S1535-6108(25)00256-9. doi: 10.1016/j.ccell.2025.06.006. Online ahead of print. Cancer Cell. 2025. PMID: 40578360
Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease.
Shi L, Uzuni A, Wang XK, Pressler M, Harle DW, Chakrabarti S, Macedo R, Belay K, Gordillo CA, Raps E, Zhang JYA, Nazaret A, Fan JL, Jin Y, Shen X, Fuller JS, Azad T, Huang J, Chainani P, Abrams JA, Del Portillo A, Mapara MY, Alhamar M, Sykes M, McFaline-Figueroa JL, Azizi E, Reshef R. Shi L, et al. Among authors: harle dw. bioRxiv [Preprint]. 2025 May 28:2025.05.24.655962. doi: 10.1101/2025.05.24.655962. bioRxiv. 2025. PMID: 40501545 Free PMC article. Preprint.
A CXCR4 partial agonist improves immunotherapy by targeting polymorphonuclear myeloid-derived suppressor cells and cancer-driven granulopoiesis.
Qian J, Ma C, Waterbury QT, Zhi X, Moon CS, Tu R, Kobayashi H, Wu F, Zheng B, Zeng Y, Zheng H, Ochiai Y, White RA, Harle DW, LaBella JS, Zamechek LB, Hu LZ, Moy RH, Han AS, Daugherty B, Lederman S, Wang TC. Qian J, et al. Among authors: harle dw. bioRxiv [Preprint]. 2024 Oct 11:2024.10.09.617228. doi: 10.1101/2024.10.09.617228. bioRxiv. 2024. PMID: 39416177 Free PMC article. Preprint.