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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis.
Qian J, Ma C, Waterbury QT, Zhi X, Moon CS, Tu R, Kobayashi H, Wu F, Zheng B, Zeng Y, Zheng H, Ochiai Y, White RA, Harle DW, LaBella JS, Zamechek LB, ZhongMing Hu L, Moy RH, Han AS, Daugherty BL, Lederman S, Wang TC. Qian J, et al. Among authors: labella js. Cancer Cell. 2025 Jun 21:S1535-6108(25)00256-9. doi: 10.1016/j.ccell.2025.06.006. Online ahead of print. Cancer Cell. 2025. PMID: 40578360
A CXCR4 partial agonist improves immunotherapy by targeting polymorphonuclear myeloid-derived suppressor cells and cancer-driven granulopoiesis.
Qian J, Ma C, Waterbury QT, Zhi X, Moon CS, Tu R, Kobayashi H, Wu F, Zheng B, Zeng Y, Zheng H, Ochiai Y, White RA, Harle DW, LaBella JS, Zamechek LB, Hu LZ, Moy RH, Han AS, Daugherty B, Lederman S, Wang TC. Qian J, et al. Among authors: labella js. bioRxiv [Preprint]. 2024 Oct 11:2024.10.09.617228. doi: 10.1101/2024.10.09.617228. bioRxiv. 2024. PMID: 39416177 Free PMC article. Preprint.
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression.
Kobayashi H, Iida T, Ochiai Y, Malagola E, Zhi X, White RA, Qian J, Wu F, Waterbury QT, Tu R, Zheng B, LaBella JS, Zamechek LB, Ogura A, Woods SL, Worthley DL, Enomoto A, Wang TC. Kobayashi H, et al. Among authors: labella js. Cancer Discov. 2025 Jan 13;15(1):202-226. doi: 10.1158/2159-8290.CD-24-0287. Cancer Discov. 2025. PMID: 39137067
Acute Intestinal Inflammation Depletes/Recruits Histamine-Expressing Myeloid Cells From the Bone Marrow Leading to Exhaustion of MB-HSCs.
Fu N, Wu F, Jiang Z, Kim W, Ruan T, Malagola E, Ochiai Y, Nápoles OC, Valenti G, White RA, Belin BR, Zamechek LB, LaBella JS, Wang TC. Fu N, et al. Among authors: labella js. Cell Mol Gastroenterol Hepatol. 2021;11(4):1119-1138. doi: 10.1016/j.jcmgh.2020.11.007. Epub 2020 Nov 26. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33249238 Free PMC article.