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Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Murakami T, Li S, Han Q, Tan Y, Kiyuna T, Igarashi K, Kawaguchi K, Hwang HK, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Hiroshima Y, Lwin TM, DeLong JC, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. Murakami T, et al. Among authors: bouvet m. Oncotarget. 2017 May 30;8(22):35630-35638. doi: 10.18632/oncotarget.15823. Oncotarget. 2017. PMID: 28404944 Free PMC article.
Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Lwin TM, Higuchi T, Kiyuna T, Miyake M, Oshiro H, Bouvet M, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: bouvet m. Cell Cycle. 2018;17(7):868-873. doi: 10.1080/15384101.2018.1445907. Epub 2018 May 21. Cell Cycle. 2018. PMID: 29623758 Free PMC article.
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Kawaguchi K, Miyake K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, Miyake M, Higuchi T, Oshiro H, Zhang Z, Razmjooei S, Wangsiricharoen S, Bouvet M, Singh SR, Unno M, Hoffman RM. Kawaguchi K, et al. Among authors: bouvet m. Cancer Lett. 2018 Sep 28;432:251-259. doi: 10.1016/j.canlet.2018.06.016. Epub 2018 Jun 18. Cancer Lett. 2018. PMID: 29928962
619 results