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Mesothelin is a surface antigen present on human meningioma and can be effectively targeted by CAR T-cells.
Ramapriyan R, Barker FG 2nd, Richardson LG, Sun J, Vandecandelaere G, Shim JM, De Vlaminck G, Gaffey M, Grewal EP, Tazhibi M, Morshedy K, Aref AR, Batool SM, Guo X, Ijad N, Balaj L, Wakimoto H, Martinez-Lage M, Frigault MJ, Leick MB, Bernstock JD, Bi WL, Carter BS, Chiocca EA, Dietrich J, Gerstner ER, Boland GM, Nahed BV, Plotkin SR, Jenkins RW, Brastianos PK, Curry WT, Maus MV, Choi BD. Ramapriyan R, et al. Among authors: jenkins rw. Neuro Oncol. 2025 Jun 28:noaf155. doi: 10.1093/neuonc/noaf155. Online ahead of print. Neuro Oncol. 2025. PMID: 40579924
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants.
Revach OY, Cicerchia AM, Shorer O, Palin CA, Petrova B, Anderson S, Liu B, Park J, Chen L, Mehta A, Wright SJ, McNamee N, Tal-Mason A, Cattaneo G, Tiwari P, Xie H, Sweere JM, Cheng LC, Sigal N, Enrico E, Miljkovic M, Evans SA, Nguyen N, Whidden ME, Srinivasan R, Spitzer MH, Sun Y, Sharova T, Lawless AR, Michaud WA, Rasmussen MQ, Fang J, Brook JR, Chen F, Wang X, Ferrone CR, Lawrence DP, Sullivan RJ, Liu D, Sachdeva UM, Sen DR, Flaherty KT, Manguso RT, Bod L, Kellis M, Boland GM, Yizhak K, Yang J, Kanarek N, Sade-Feldman M, Hacohen N, Jenkins RW. Revach OY, et al. Among authors: jenkins rw. Cell Rep Med. 2025 Jun 19:102210. doi: 10.1016/j.xcrm.2025.102210. Online ahead of print. Cell Rep Med. 2025. PMID: 40578364 Free article.
SITC vision: Opportunities for deeper understanding of mechanisms of anti-tumor activity, toxicity, and resistance to optimize cancer immunotherapy.
Sullivan RJ, Cillo AR, Ferris RL, Jenkins RW, Kluger HM, Kok M, Lipson EJ, Paruzzo L, Redmond WL, Ruella M, Schalper KA, Thommen DS, Tolley K, Yarchoan M, Garnett-Benson C. Sullivan RJ, et al. Among authors: jenkins rw. J Immunother Cancer. 2025 Jun 25;13(6):e011929. doi: 10.1136/jitc-2025-011929. J Immunother Cancer. 2025. PMID: 40562704 Free PMC article.
Use of patient-derived organotypic tumor spheroids for testing of viral vector gene therapy in combination with checkpoint blockade.
Domingues ACM, de Oliveira SB, Tessarollo NG, Lepique AP, Rodrigues O, Sharova T, Lawless A, Li D, Basnet M, Boland GM, Cohen S, Jenkins RW, Strauss BE. Domingues ACM, et al. Among authors: jenkins rw. Mol Ther Oncol. 2025 Jan 28;33(1):200942. doi: 10.1016/j.omton.2025.200942. eCollection 2025 Mar 20. Mol Ther Oncol. 2025. PMID: 40034966 Free PMC article.
Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity.
Lunavat TR, Nieland L, van de Looij SM, de Reus AJEM, Couturier CP, Farran CAE, Miller TE, Lill JK, Schübel M, Xiao T, Ianni ED, Woods EC, Sun Y, Rufino-Ramos D, van Solinge TS, Mahjoum S, Grandell E, Li M, Mangena V, Dunn GP, Jenkins RW, Mempel TR, Breakefield XO, Breyne K. Lunavat TR, et al. Among authors: jenkins rw. bioRxiv [Preprint]. 2025 Feb 5:2025.02.03.636330. doi: 10.1101/2025.02.03.636330. bioRxiv. 2025. PMID: 39975249 Free PMC article. Preprint.
Mechanical signatures in cancer metastasis.
Agrawal A, Javanmardi Y, Watson SA, Serwinski B, Djordjevic B, Li W, Aref AR, Jenkins RW, Moeendarbary E. Agrawal A, et al. Among authors: jenkins rw. NPJ Biol Phys Mech. 2025;2(1):3. doi: 10.1038/s44341-024-00007-x. Epub 2025 Feb 4. NPJ Biol Phys Mech. 2025. PMID: 39917412 Free PMC article. Review.
TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids.
Sun Y, Maggs L, Panda A, Wright SJ, Cicerchia AM, Jenney A, Perricone MD, Mills CE, Cattaneo G, Ventin M, Chen F, Rasmussen MQ, Miranda A, Revach OY, Fang J, Fu A, Bowling PJ, Sharova T, Lawless A, Sorger PK, Bardeesy N, Wang X, Flaherty KT, Boland GM, Mehta A, Sade-Feldman M, Ferrone CR, Jenkins RW. Sun Y, et al. Among authors: jenkins rw. Cancer Immunol Res. 2025 Feb 3;13(2):210-228. doi: 10.1158/2326-6066.CIR-23-1011. Cancer Immunol Res. 2025. PMID: 39785827
Potent antitumor activity of a designed interleukin-21 mimic.
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D. Chun JH, et al. Among authors: jenkins rw. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.626481. doi: 10.1101/2024.12.06.626481. bioRxiv. 2024. PMID: 39677740 Free PMC article. Preprint.
Overcoming Resistance Mechanisms to Melanoma Immunotherapy.
Zheng DX, Bozym DJ, Tarantino G, Sullivan RJ, Liu D, Jenkins RW. Zheng DX, et al. Among authors: jenkins rw. Am J Clin Dermatol. 2025 Jan;26(1):77-96. doi: 10.1007/s40257-024-00907-7. Epub 2024 Dec 5. Am J Clin Dermatol. 2025. PMID: 39636504 Review.
84 results