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Page 1
Mesothelin is a surface antigen present on human meningioma and can be effectively targeted by CAR T-cells.
Ramapriyan R, Barker FG 2nd, Richardson LG, Sun J, Vandecandelaere G, Shim JM, De Vlaminck G, Gaffey M, Grewal EP, Tazhibi M, Morshedy K, Aref AR, Batool SM, Guo X, Ijad N, Balaj L, Wakimoto H, Martinez-Lage M, Frigault MJ, Leick MB, Bernstock JD, Bi WL, Carter BS, Chiocca EA, Dietrich J, Gerstner ER, Boland GM, Nahed BV, Plotkin SR, Jenkins RW, Brastianos PK, Curry WT, Maus MV, Choi BD. Ramapriyan R, et al. Among authors: leick mb. Neuro Oncol. 2025 Jun 28:noaf155. doi: 10.1093/neuonc/noaf155. Online ahead of print. Neuro Oncol. 2025. PMID: 40579924
IFN-γ-resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models.
Bailey SR, Takei HN, Escobar G, Kann MC, Bouffard AA, Kienka T, Supper VM, Armstrong A, Salas-Benito D, Phillips MK, Birocchi F, Vatsa S, Silva H, Scarfò I, Wehrli M, Grauwet K, Darnell EP, Graham CE, Leick MB, Korell F, Berger TR, Maus MV. Bailey SR, et al. Among authors: leick mb. Sci Transl Med. 2025 Jun 4;17(801):eadp8166. doi: 10.1126/scitranslmed.adp8166. Epub 2025 Jun 4. Sci Transl Med. 2025. PMID: 40465687
Secretion of a VEGF-blocking scFv enhances CAR T-cell potency.
Supper VM, Donner H, Birocchi F, Bratt A, Escobar G, Kann MC, Park S, Martin G, Korell F, Takei H, Armstrong A, Parker A, Salas-Benito D, Darnell EP, Bailey SR, Kienka T, Philips M, Bouffard A, Goncalves S, Choi BD, Haradhvala NJ, Maus MV, Leick MB. Supper VM, et al. Among authors: leick mb. Cancer Immunol Res. 2025 Jun 2. doi: 10.1158/2326-6066.CIR-24-0876. Online ahead of print. Cancer Immunol Res. 2025. PMID: 40455064
Single-cell dynamics of breakthrough toxicities after anakinra prophylaxis for axicabtagene ciloleucel in lymphoma.
Frigault MJ, Yao N, Berger TR, Wehrli M, Gallagher KME, Horick N, Graham CE, Jacobson CA, Chen YB, Leick MB, DeFilipp Z, El-Jawahri AR, Johnson PC, Dolaher M, Katsis K, Kim AI, Crombie J, Merryman RW, Cook D, Trailor M, Cho H, Jeffrey R 3rd, Shen R, Filosto S, Nater J, Getz G, Haradhvala NJ, Maus MV. Frigault MJ, et al. Among authors: leick mb. Blood Adv. 2025 May 13;9(9):2122-2135. doi: 10.1182/bloodadvances.2024015161. Blood Adv. 2025. PMID: 39928957 Free PMC article. Clinical Trial.
Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics.
Korell F, Olson ML, Salas-Benito D, Leick MB, Larson RC, Bouffard A, Silva H, Gasparetto A, Berger TR, Kann MC, Mergen M, Kienka T, Wehrli M, Haradhvala NJ, Bailey SR, Letai A, Maus MV. Korell F, et al. Among authors: leick mb. Sci Transl Med. 2024 Jun 5;16(750):eadk7640. doi: 10.1126/scitranslmed.adk7640. Epub 2024 Jun 5. Sci Transl Med. 2024. PMID: 38838132 Free PMC article.
Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+ lymphoid malignancies.
Frigault MJ, Graham CE, Berger TR, Ritchey J, Horick NK, El-Jawahri A, Scarfò I, Schmidts A, Haradhvala NJ, Wehrli M, Lee WH, Parker AL, Wiggin HR, Bouffard A, Dey A, Leick MB, Katsis K, Elder EL, Dolaher MA, Cook DT, Chekmasova AA, Huang L, Nikiforow S, Daley H, Ritz J, Armant M, Preffer F, DiPersio JF, Nardi V, Chen YB, Gallagher KME, Maus MV. Frigault MJ, et al. Among authors: leick mb. Blood. 2024 Sep 12;144(11):1153-1167. doi: 10.1182/blood.2024024104. Blood. 2024. PMID: 38781564 Clinical Trial.
Stealth transgenes enable CAR-T cells to evade host immune responses.
Grauwet K, Berger T, Kann MC, Silva H, Larson R, Leick MB, Bailey SR, Bouffard AA, Millar D, Gallagher K, Turtle CJ, Frigault MJ, Maus MV. Grauwet K, et al. Among authors: leick mb. J Immunother Cancer. 2024 May 9;12(5):e008417. doi: 10.1136/jitc-2023-008417. J Immunother Cancer. 2024. PMID: 38724463 Free PMC article.
Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma.
Choi BD, Gerstner ER, Frigault MJ, Leick MB, Mount CW, Balaj L, Nikiforow S, Carter BS, Curry WT, Gallagher K, Maus MV. Choi BD, et al. Among authors: leick mb. N Engl J Med. 2024 Apr 11;390(14):1290-1298. doi: 10.1056/NEJMoa2314390. Epub 2024 Mar 13. N Engl J Med. 2024. PMID: 38477966 Free PMC article.
41 results