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Mesothelin is a surface antigen present on human meningioma and can be effectively targeted by CAR T-cells.
Ramapriyan R, Barker FG 2nd, Richardson LG, Sun J, Vandecandelaere G, Shim JM, De Vlaminck G, Gaffey M, Grewal EP, Tazhibi M, Morshedy K, Aref AR, Batool SM, Guo X, Ijad N, Balaj L, Wakimoto H, Martinez-Lage M, Frigault MJ, Leick MB, Bernstock JD, Bi WL, Carter BS, Chiocca EA, Dietrich J, Gerstner ER, Boland GM, Nahed BV, Plotkin SR, Jenkins RW, Brastianos PK, Curry WT, Maus MV, Choi BD. Ramapriyan R, et al. Among authors: plotkin sr. Neuro Oncol. 2025 Jun 28:noaf155. doi: 10.1093/neuonc/noaf155. Online ahead of print. Neuro Oncol. 2025. PMID: 40579924
Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104.
Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR; Neurofibromatosis Clinical Trials Consortium. Nakhate V, et al. Among authors: plotkin sr. J Neurooncol. 2025 Jul;173(3):751-757. doi: 10.1007/s11060-025-05020-1. Epub 2025 May 28. J Neurooncol. 2025. PMID: 40434540 Clinical Trial.
A single-cell atlas of Schwannoma across genetic backgrounds and anatomic locations.
Gonzalez Castro LN, Gavish A, Bussema L, Mount CW, Neftel C, Nomura M, Chiocca EA, Bi WL, Arnaout O, Barker FG 2nd, Brown JM, Jordan JT, Batchelor TT, Stemmer-Rachamimov A, Plotkin SR, Tirosh I, Suvà ML. Gonzalez Castro LN, et al. Among authors: plotkin sr. Genome Med. 2025 Apr 11;17(1):37. doi: 10.1186/s13073-025-01462-4. Genome Med. 2025. PMID: 40217315 Free PMC article.
Enhanced Tumor Control and Hearing Loss Prevention Achieved with Combined Immune Checkpoint Inhibitor and Anti-VEGF Therapy in Vestibular Schwannoma Model.
Lu S, Yin Z, Wu L, Sun Y, Chen J, Wu LMN, Oblinger JL, Blake DC, Landegger LD, Seist R, Ho W, Xiu B, Jones AP, Muzikansky A, Stankovic KM, Plotkin SR, Chang LS, Xu L. Lu S, et al. Among authors: plotkin sr. bioRxiv [Preprint]. 2024 Dec 29:2024.12.29.630658. doi: 10.1101/2024.12.29.630658. bioRxiv. 2024. PMID: 39763968 Free PMC article. Preprint.
Phase 1b/2 study of orally administered pexidartinib in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma.
Mendez JS, Cohen AL, Eckenstein M, Jensen RL, Burt LM, Salzman KL, Chamberlain M, Hsu HH, Hutchinson M, Iwamoto F, Ligon KL, Mrugala MM, Pelayo M, Plotkin SR, Puduvalli VK, Raizer J, Reardon DA, Sterba M, Walbert T, West BL, Wong ET, Zhang C, Colman H. Mendez JS, et al. Among authors: plotkin sr. Neurooncol Adv. 2024 Nov 22;6(1):vdae202. doi: 10.1093/noajnl/vdae202. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 39734810 Free PMC article.
202 results