Ploegh HL - Search Results

1

MHC II-restricted presentation of soluble antigen by naïve B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity.

Steiner TM, Kato Y, Tan PS, Tullett KM, Panetta F, Davey GM, Ploegh HL, Lahoud MH, Fernandez-Ruiz D, Caminschi I, Heath WR. Steiner TM, et al. Among authors: ploegh hl. J Immunol. 2025 Jun 23:vkaf129. doi: 10.1093/jimmun/vkaf129. Online ahead of print. J Immunol. 2025. PMID: 40581630

2

Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations.

Watson SM, Harvey EP, Pishesha N, Ploegh HL, Springer TA. Watson SM, et al. Among authors: ploegh hl. J Biol Chem. 2025 Jun 12:110374. doi: 10.1016/j.jbc.2025.110374. Online ahead of print. J Biol Chem. 2025. PMID: 40516870 Free article.

3

Site-specific labeling uncovers differences in levels and distribution of B-cell receptors of different isotypes on primary B cells.

Bousbaine D, Obeng EM, Li Z, Fang T, Cheloha RW, Ploegh HL, McCaul N. Bousbaine D, et al. Among authors: ploegh hl. J Immunol. 2025 May 2:vkaf062. doi: 10.1093/jimmun/vkaf062. Online ahead of print. J Immunol. 2025. PMID: 40314988

4

A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses.

Liu X, Balligand T, Le Gall C, Ploegh HL. Liu X, et al. Among authors: ploegh hl. Proc Natl Acad Sci U S A. 2025 Apr 15;122(15):e2424889122. doi: 10.1073/pnas.2424889122. Epub 2025 Apr 7. Proc Natl Acad Sci U S A. 2025. PMID: 40193611

5

Nanobody-Targeted Conditional Antimicrobial Therapeutics.

Ngambenjawong C, Ko H, Samad T, Pishesha N, Ploegh HL, Bhatia SN. Ngambenjawong C, et al. Among authors: ploegh hl. ACS Nano. 2025 Mar 18;19(10):9958-9970. doi: 10.1021/acsnano.4c16007. Epub 2025 Mar 5. ACS Nano. 2025. PMID: 40044143 Free PMC article.

6

Imaging the immune sequelae of infection with SARS-CoV-2 in nonhuman primates by using two nanobody PET-tracers.

Koopman G, Verhoeven T, Mooij P, Acar RF, Harmand T, Flanagan L, Bakker J, Böszörményi KP, Bontrop RE, Langermans JAM, Ploegh HL, Verschoor EJ, Vugts DJ, Pishesha N, Stammes MA. Koopman G, et al. Among authors: ploegh hl. J Med Virol. 2024 Oct;96(10):e29956. doi: 10.1002/jmv.29956. J Med Virol. 2024. PMID: 39400953

7

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

Schiffelers LDJ, Tesfamariam YM, Jenster LM, Diehl S, Binder SC, Normann S, Mayr J, Pritzl S, Hagelauer E, Kopp A, Alon A, Geyer M, Ploegh HL, Schmidt FI. Schiffelers LDJ, et al. Among authors: ploegh hl. Nat Commun. 2024 Sep 26;15(1):8266. doi: 10.1038/s41467-024-52110-1. Nat Commun. 2024. PMID: 39327452 Free PMC article.

8

A monoclonal antibody that recognizes a unique 13-residue epitope in the cytoplasmic tail of HLA-E.

Verhaar ER, Gan J, Buhl S, Li Z, Horowitz A, Ploegh HL. Verhaar ER, et al. Among authors: ploegh hl. Mol Immunol. 2024 Aug;172:56-67. doi: 10.1016/j.molimm.2024.06.004. Epub 2024 Jun 19. Mol Immunol. 2024. PMID: 38901180

9

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages.

Bates TA, Trank-Greene M, Wrynla XH, Anastas A, Gurmessa SK, Merutka IR, Dixon SD, Shumate A, Groncki AR, Parson MAH, Ingram JR, Barklis E, Burke JE, Shinde U, Ploegh HL, Tafesse FG. Bates TA, et al. Among authors: ploegh hl. Elife. 2024 May 28;12:RP91930. doi: 10.7554/eLife.91930. Elife. 2024. PMID: 38805257 Free PMC article.

10

Nanobody-based CAR NK cells for possible immunotherapy of MICA⁺ tumors.

Verhaar ER, van Keizerswaard WJC, Knoflook A, Balligand T, Ploegh HL. Verhaar ER, et al. Among authors: ploegh hl. PNAS Nexus. 2024 May 6;3(5):pgae184. doi: 10.1093/pnasnexus/pgae184. eCollection 2024 May. PNAS Nexus. 2024. PMID: 38756234 Free PMC article.

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