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Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.
Trasviña-Arenas CH, Dissanayake UC, Tamayo N, Hashemian M, Lin WJ, Demir M, Hoyos-Gonzalez N, Fisher AJ, Cisneros GA, Horvath MP, David SS. Trasviña-Arenas CH, et al. Among authors: david ss. Nat Commun. 2025 Apr 16;16(1):3596. doi: 10.1038/s41467-025-58361-w. Nat Commun. 2025. PMID: 40234396 Free PMC article.
148 results