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Page 1
Restoring p53 wild-type conformation in TP53-Y220C-mutant acute myeloid leukemia.
Carter BZ, Mak PY, Ayoub E, Wu X, Ke B, Nishida Y, Futreal A, Ostermann LB, Bedoy AD, Boettcher S, DiNardo CD, Puzio-Kuter A, Poyurovsky MV, Levine AJ, Andreeff M. Carter BZ, et al. Among authors: poyurovsky mv. Blood. 2025 Jul 3:blood.2025028935. doi: 10.1182/blood.2025028935. Online ahead of print. Blood. 2025. PMID: 40608889
Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator.
Puzio-Kuter AM, Xu L, McBrayer MK, Dominique R, Li HH, Fahr BJ, Brown AM, Wiebesiek AE, Russo BM, Mulligan CL, Yang H, Battaglia J, Robell KA, Thomas DH, Huang KS, Solovyov A, Greenbaum BD, Oliner JD, Davis TW, Dumble ML, Johnson ML, Xiong S, Yang P, Lozano G, Fellous MM, Vu BT, Schram AM, Levine AJ, Poyurovsky MV. Puzio-Kuter AM, et al. Among authors: poyurovsky mv. Cancer Discov. 2025 Jun 3;15(6):1159-1179. doi: 10.1158/2159-8290.CD-24-1421. Cancer Discov. 2025. PMID: 39945593 Free PMC article.
Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival.
Komza M, Khatun J, Gelles JD, Trotta AP, Abraham-Enachescu I, Henao J, Elsaadi A, Kotini AG, Clementelli C, Arandela J, Ghaity-Beckley SE, Barua A, Chen Y, Berisa M, Marcellino BK, Papapetrou EP, Poyurovsky MV, Chipuk JE. Komza M, et al. Among authors: poyurovsky mv. Cell Commun Signal. 2025 Jan 25;23(1):47. doi: 10.1186/s12964-025-02044-y. Cell Commun Signal. 2025. PMID: 39863913 Free PMC article.
Metabolic Adaptations To Acute Glucose Uptake Inhibition Converge Upon Mitochondrial Respiration For Leukemia Cell Survival.
Komza M, Khatun J, Gelles JD, Trotta AP, Abraham-Enachescu I, Henao J, Elsaadi A, Kotini AG, Clementelli C, Arandela J, El Ghaity-Beckley S, Barua A, Chen Y, Marcellino BK, Papapetrou EP, Poyurovsky MV, Chipuk JE. Komza M, et al. Among authors: poyurovsky mv. bioRxiv [Preprint]. 2024 Nov 22:2024.11.20.624567. doi: 10.1101/2024.11.20.624567. bioRxiv. 2024. Update in: Cell Commun Signal. 2025 Jan 25;23(1):47. doi: 10.1186/s12964-025-02044-y. PMID: 39713344 Free PMC article. Updated. Preprint.
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers.
Mao C, Lei G, Horbath A, Wang M, Lu Z, Yan Y, Liu X, Kondiparthi L, Chen X, Cheng J, Li Q, Xu Z, Zhuang L, Fang B, Marszalek JR, Poyurovsky MV, Olszewski K, Gan B. Mao C, et al. Among authors: poyurovsky mv. Mol Cell. 2024 May 16;84(10):1964-1979.e6. doi: 10.1016/j.molcel.2024.04.009. Mol Cell. 2024. PMID: 38759628 Free PMC article.
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance.
Lee H, Horbath A, Kondiparthi L, Meena JK, Lei G, Dasgupta S, Liu X, Zhuang L, Koppula P, Li M, Mahmud I, Wei B, Lorenzi PL, Keyomarsi K, Poyurovsky MV, Olszewski K, Gan B. Lee H, et al. Among authors: poyurovsky mv. Nat Commun. 2024 Jan 2;15(1):79. doi: 10.1038/s41467-023-44412-7. Nat Commun. 2024. PMID: 38167301 Free PMC article.
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.
Mooring M, Yeung GA, Luukkonen P, Liu S, Akbar MW, Zhang GJ, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky MV, Booth CJ, Konnikova L, Shulman GI, Yimlamai D. Mooring M, et al. Among authors: poyurovsky mv. Sci Transl Med. 2023 Sep 27;15(715):eade3157. doi: 10.1126/scitranslmed.ade3157. Epub 2023 Sep 27. Sci Transl Med. 2023. PMID: 37756381 Free PMC article.
Spatial mapping of mitochondrial networks and bioenergetics in lung cancer.
Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. Han M, et al. Among authors: poyurovsky mv. Nature. 2023 Mar;615(7953):712-719. doi: 10.1038/s41586-023-05793-3. Epub 2023 Mar 15. Nature. 2023. PMID: 36922590 Free PMC article.
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.
Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Liu X, et al. Among authors: poyurovsky mv. Nat Cell Biol. 2023 Mar;25(3):404-414. doi: 10.1038/s41556-023-01091-2. Epub 2023 Feb 6. Nat Cell Biol. 2023. PMID: 36747082 Free PMC article.
39 results