Streets AJ - Search Results

1

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.

Smith CEL, Streets AJ, Lake AVR, Natarajan S, Best SK, Szymanska K, Karwatka M, Stevenson T, Trowbridge R, Grant G, Grellscheid SN, Foster R, Morrison CG, Mavria G, Bond J, Ong ACM, Johnson CA. Smith CEL, et al. Among authors: streets aj. Commun Med (Lond). 2025 Apr 19;5(1):129. doi: 10.1038/s43856-025-00847-1. Commun Med (Lond). 2025. PMID: 40253509 Free PMC article.

2

BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD.

Tran U, Streets AJ, Smith D, Decker E, Kirschfink A, Izem L, Hassey JM, Rutland B, Valluru MK, Bräsen JH, Ott E, Epting D, Eisenberger T, Ong AC, Bergmann C, Wessely O. Tran U, et al. Among authors: streets aj. bioRxiv [Preprint]. 2025 Mar 10:2024.08.27.608867. doi: 10.1101/2024.08.27.608867. bioRxiv. 2025. PMID: 39253489 Free PMC article. Preprint.

3

The association of urinary epidermal growth factors with ADPKD disease severity and progression.

Harskamp LR, Perez-Gomez MV, Heida JE, Engels GE, van Goor H, van den Heuvel MC, Streets AJ, Ong ACM, Ortiz A, Gansevoort RT; DIPAK Consortium. Harskamp LR, et al. Among authors: streets aj. Nephrol Dial Transplant. 2023 Sep 29;38(10):2266-2275. doi: 10.1093/ndt/gfad050. Nephrol Dial Transplant. 2023. PMID: 36914219 Free PMC article.

4

Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling.

Streets AJ, Prosseda PP, Ong AC. Streets AJ, et al. JCI Insight. 2020 Aug 20;5(16):e135385. doi: 10.1172/jci.insight.135385. JCI Insight. 2020. PMID: 32663194 Free PMC article.

5

Global microRNA profiling in human urinary exosomes reveals novel disease biomarkers and cellular pathways for autosomal dominant polycystic kidney disease.

Magayr TA, Song X, Streets AJ, Vergoz L, Chang L, Valluru MK, Yap HL, Lannoy M, Haghighi A, Simms RJ, Tam FWK, Pei Y, Ong ACM. Magayr TA, et al. Among authors: streets aj. Kidney Int. 2020 Aug;98(2):420-435. doi: 10.1016/j.kint.2020.02.008. Epub 2020 Mar 6. Kidney Int. 2020. PMID: 32622528 Free article.

6

The positive effect of selective prostaglandin E2 receptor EP2 and EP4 blockade on cystogenesis in vitro is counteracted by increased kidney inflammation in vivo.

Lannoy M, Valluru MK, Chang L, Abdela-Ali F, Peters DJM, Streets AJ, Ong ACM. Lannoy M, et al. Among authors: streets aj. Kidney Int. 2020 Aug;98(2):404-419. doi: 10.1016/j.kint.2020.02.012. Epub 2020 Mar 6. Kidney Int. 2020. PMID: 32622526 Free article.

7

A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2^-/- phenotype.

Metzner A, Griffiths JD, Streets AJ, Markham E, Philippou T, Van Eeden FJM, Ong ACM. Metzner A, et al. Among authors: streets aj. Sci Rep. 2020 Jan 9;10(1):72. doi: 10.1038/s41598-019-56995-7. Sci Rep. 2020. PMID: 31919453 Free PMC article.

8

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex.

Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L, Ong ACM. Feng S, et al. Among authors: streets aj. J Am Soc Nephrol. 2017 Oct;28(10):2973-2984. doi: 10.1681/ASN.2016121349. Epub 2017 Jun 15. J Am Soc Nephrol. 2017. PMID: 28620080 Free PMC article.

9

Parallel microarray profiling identifies ErbB4 as a determinant of cyst growth in ADPKD and a prognostic biomarker for disease progression.

Streets AJ, Magayr TA, Huang L, Vergoz L, Rossetti S, Simms RJ, Harris PC, Peters DJ, Ong AC. Streets AJ, et al. Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F577-F588. doi: 10.1152/ajprenal.00607.2016. Epub 2017 Jan 11. Am J Physiol Renal Physiol. 2017. PMID: 28077374 Free PMC article.

10

The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.

Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga JP, Wessely O, Williamson MP, Ong AC. Xu Y, et al. Among authors: streets aj. J Am Soc Nephrol. 2016 Apr;27(4):1159-73. doi: 10.1681/ASN.2014111074. Epub 2015 Aug 26. J Am Soc Nephrol. 2016. PMID: 26311459 Free PMC article.

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