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Blood biomarkers for Alzheimer's disease and related disorders.
Zetterberg H, Schott JM. Zetterberg H, et al. Acta Neurol Scand. 2022 Jul;146(1):51-55. doi: 10.1111/ane.13628. Epub 2022 Apr 25. Acta Neurol Scand. 2022. PMID: 35470421 Review.
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the single commonest cause of dementia. Many other diseases can, however, cause dementia, and differential diagnosis can be challenging, especially in early disease stages. …
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the single commonest cause of dementia. …
Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer's risk-enhanced sample.
Du L, Langhough RE, Wilson RE, Reyes RER, Hermann BP, Jonaitis EM, Betthauser TJ, Chin NA, Christian B, Chaby L, Jeromin A, Molfetta GD, Brum WS, Arslan B, Ashton N, Blennow K, Zetterberg H, Johnson SC. Du L, et al. Alzheimers Dement. 2024 Sep;20(9):6183-6204. doi: 10.1002/alz.14100. Epub 2024 Jul 5. Alzheimers Dement. 2024. PMID: 38970274 Free PMC article.
INTRODUCTION: Understanding longitudinal change in key plasma biomarkers will aid in detecting presymptomatic Alzheimer's disease (AD). METHODS: Serial plasma samples from 424 Wisconsin Registry for Alzheimer's Prevention participants were analy …
INTRODUCTION: Understanding longitudinal change in key plasma biomarkers will aid in detecting presymptomatic Alzheimer's d …
The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-beta positivity.
Arslan B, Brum WS, Pola I, Therriault J, Rahmouni N, Stevenson J, Servaes S, Tan K, Vitali P, Montembeault M, Klostranec J, Macedo AC, Tissot C, Gauthier S, Lantero-Rodriguez J, Zimmer ER, Blennow K, Zetterberg H, Rosa-Neto P, Benedet AL, Ashton NJ. Arslan B, et al. Alzheimers Res Ther. 2025 Feb 19;17(1):48. doi: 10.1186/s13195-025-01692-z. Alzheimers Res Ther. 2025. PMID: 39972340 Free PMC article.
BACKGROUND: Impaired kidney function has a potential confounding effect on blood biomarker levels, including biomarkers for Alzheimer's disease (AD). Given the imminent use of certain blood biomarkers in the routine diagnostic work-up of patients with suspect …
BACKGROUND: Impaired kidney function has a potential confounding effect on blood biomarker levels, including biomarkers for Alzheimer …
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly.
Koivumäki M, Ekblad L, Lantero-Rodriguez J, Ashton NJ, Karikari TK, Helin S, Parkkola R, Lötjönen J, Zetterberg H, Blennow K, Rinne JO, Snellman A. Koivumäki M, et al. Alzheimers Res Ther. 2024 May 18;16(1):112. doi: 10.1186/s13195-024-01477-w. Alzheimers Res Ther. 2024. PMID: 38762725 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-beta (Abeta) plaques, neurofibrillary tau tangles, and neurodegeneration in the brain parenchyma. ...
BACKGROUND: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-beta (Abeta) plaques, neurofibrill …
Soluble Abeta pathology predicts neurodegeneration and cognitive decline independently on p-tau in the earliest Alzheimer's continuum: Evidence across two independent cohorts.
Cacciaglia R, Falcón C, Benavides GS, Brugulat-Serrat A, Alomà MM, Calvet MS, Molinuevo JL, Fauria K, Minguillón C, Kollmorgen G, Quijano-Rubio C, Blennow K, Zetterberg H, Lorenzini L, Wink AM, Ingala S, Barkhof F, Ritchie CW, Gispert JD; ALFA study. Cacciaglia R, et al. Alzheimers Dement. 2025 Feb;21(2):e14415. doi: 10.1002/alz.14415. Epub 2025 Feb 3. Alzheimers Dement. 2025. PMID: 39898436 Free PMC article.
INTRODUCTION: Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to the discovery of preventive strategies. ...Our results underscore the importance of undertaking …
INTRODUCTION: Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in …