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Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262).
Taiwo B, Zheng L, Gallien S, Matining RM, Kuritzkes DR, Wilson CC, Berzins BI, Acosta EP, Bastow B, Kim PS, Eron JJ Jr; ACTG A5262 Team. Taiwo B, et al. AIDS. 2011 Nov 13;25(17):2113-22. doi: 10.1097/QAD.0b013e32834bbaa9. AIDS. 2011. PMID: 21857490 Free PMC article. Clinical Trial.
METHODS: One hundred and twelve antiretroviral-naive, HIV-1-infected patients received DRV/r 800/100 mg once daily and RAL 400 mg twice daily. ...When trough RAL concentrations were included as a time-varying covariate in the analysis, virologic failure remained associated …
METHODS: One hundred and twelve antiretroviral-naive, HIV-1-infected patients received DRV/r 800/100 mg once daily and RAL 400 mg twi …
Uridine supplementation in the treatment of HIV lipoatrophy: results of ACTG 5229.
McComsey GA, Walker UA, Budhathoki CB, Su Z, Currier JS, Kosmiski L, Naini LG, Charles S, Medvik K, Aberg JA; AIDS Clinical Trials Group A5229 Team. McComsey GA, et al. AIDS. 2010 Oct 23;24(16):2507-15. doi: 10.1097/QAD.0b013e32833ea9bc. AIDS. 2010. PMID: 20827170 Free PMC article. Clinical Trial.
RESULTS: The 165 participants were 91% men, 62% white; median age 49 years, CD4 cell count 506 cells/mul, and limb fat 3037 g; 81% had HIV-1 RNA 50 copies/ml or less; 76% were on zidovudine (ZDV). Baseline characteristics were similar between groups. ...On as-treated analy …
RESULTS: The 165 participants were 91% men, 62% white; median age 49 years, CD4 cell count 506 cells/mul, and limb fat 3037 g; 81% had HIV- …