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The totipotent 2C-like state safeguards genomic stability of mouse embryonic stem cells.
J Cell Physiol. 2024 Sep;239(9):e31337. doi: 10.1002/jcp.31337. Epub 2024 Jun 11.
J Cell Physiol. 2024.
PMID: 38860420
Dux cluster duplication ensures full activation of totipotent genes.
Lin M, Du Z, Guo D, Zhang Y, Dan J.
Lin M, et al.
Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2421594122. doi: 10.1073/pnas.2421594122. Epub 2025 Mar 6.
Proc Natl Acad Sci U S A. 2025.
PMID: 40048272
Free PMC article.
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The ZBTB24-CDCA7-HELLS axis suppresses the totipotent 2C-like reprogramming by maintaining Dux methylation and repression.
Guo D, Du Z, Liu Y, Lin M, Lu Y, Hardikar S, Xue Y, Zhang J, Chen T, Dan J.
Guo D, et al.
Nucleic Acids Res. 2025 Apr 10;53(7):gkaf302. doi: 10.1093/nar/gkaf302.
Nucleic Acids Res. 2025.
PMID: 40226918
Free PMC article.
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