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Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C. Kowatsch C, et al. Curr Opin Struct Biol. 2019 Aug;57:204-214. doi: 10.1016/j.sbi.2019.05.015. Epub 2019 Jun 24. Curr Opin Struct Biol. 2019. PMID: 31247512 Free PMC article. Review.

Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.

Malinauskas T, Peer TV, Bishop B, Mueller TD, Siebold C. Malinauskas T, et al. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15620-15631. doi: 10.1073/pnas.2000561117. Epub 2020 Jun 23. Proc Natl Acad Sci U S A. 2020. PMID: 32576689 Free PMC article.

Calibration-free In Vitro Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software.

Nolan R, Alvarez LA, Griffiths SC, Elegheert J, Siebold C, Padilla-Parra S. Nolan R, et al. J Vis Exp. 2018 Jul 17;(137):58157. doi: 10.3791/58157. J Vis Exp. 2018. PMID: 30080195 Free PMC article.

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