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Page 1
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F. Chen F, et al. Nat Metab. 2022 May;4(5):534-546. doi: 10.1038/s42255-022-00577-x. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655026 Free PMC article.
Emerging roles of DYRK2 in cancer.
Tandon V, de la Vega L, Banerjee S. Tandon V, et al. J Biol Chem. 2021 Jan-Jun;296:100233. doi: 10.1074/jbc.REV120.015217. Epub 2021 Jan 7. J Biol Chem. 2021. PMID: 33376136 Free PMC article. Review.
Dual inhibition of HSF1 and DYRK2 impedes cancer progression.
Tandon V, Moreno R, Allmeroth K, Quinn J, Wiley SE, Nicely LG, Denzel MS, Edwards J, de la Vega L, Banerjee S. Tandon V, et al. Biosci Rep. 2023 Jan 31;43(1):BSR20222102. doi: 10.1042/BSR20222102. Biosci Rep. 2023. PMID: 36622366 Free PMC article.
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways.
Kurmasheva N, Said A, Wong B, Kinderman P, Han X, Rahimic AHF, Kress A, Carter-Timofte ME, Holm E, van der Horst D, Kollmann CF, Liu Z, Wang C, Hoang HD, Kovalenko E, Chrysopoulou M, Twayana KS, Ottosen RN, Svenningsen EB, Begnini F, Kiib AE, Kromm FEH, Weiss HJ, Di Carlo D, Muscolini M, Higgins M, van der Heijden M, Arulanandam R, Bardoul A, Tong T, Ozsvar A, Hou WH, Schack VR, Holm CK, Zheng Y, Ruzek M, Kalucka J, de la Vega L, Elgaher WAM, Korshoej AR, Lin R, Hiscott J, Poulsen TB, O'Neill LA, Roy DG, Rinschen MM, van Montfoort N, Diallo JS, Farin HF, Alain T, Olagnier D. Kurmasheva N, et al. Nat Commun. 2024 May 15;15(1):4096. doi: 10.1038/s41467-024-48422-x. Nat Commun. 2024. PMID: 38750019 Free PMC article.
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity.
Casares L, Unciti-Broceta JD, Prados ME, Caprioglio D, Mattoteia D, Higgins M, Apendino G, Dinkova-Kostova AT, Muñoz E, de la Vega L. Casares L, et al. Redox Biol. 2020 Oct;37:101689. doi: 10.1016/j.redox.2020.101689. Epub 2020 Aug 22. Redox Biol. 2020. PMID: 32863231 Free PMC article.
Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses.
Torrente L, Sanchez C, Moreno R, Chowdhry S, Cabello P, Isono K, Koseki H, Honda T, Hayes JD, Dinkova-Kostova AT, de la Vega L. Torrente L, et al. Oncogene. 2017 Nov 2;36(44):6204-6212. doi: 10.1038/onc.2017.221. Epub 2017 Jul 10. Oncogene. 2017. PMID: 28692050 Free PMC article.
A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival.
Lara-Chica M, Correa-Sáez A, Jiménez-Izquierdo R, Garrido-Rodríguez M, Ponce FJ, Moreno R, Morrison K, Di Vona C, Arató K, Jiménez-Jiménez C, Morrugares R, Schmitz ML, de la Luna S, de la Vega L, Calzado MA. Lara-Chica M, et al. Cell Death Differ. 2022 Jan;29(1):105-117. doi: 10.1038/s41418-021-00845-5. Epub 2021 Aug 6. Cell Death Differ. 2022. PMID: 34363019 Free PMC article.
19 results