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H. pylori-induced NF-κB-PIEZO1-YAP1-CTGF axis drives gastric cancer progression and cancer-associated fibroblast-mediated tumour microenvironment remodelling.
Chen B, Liu X, Yu P, Xie F, Kwan JSH, Chan WN, Fang C, Zhang J, Cheung AHK, Chow C, Leung GWM, Leung KT, Shi S, Zhang B, Wang S, Xu D, Fu K, Wong CC, Wu WKK, Chan MWY, Tang PMK, Tsang CM, Lo KW, Tse GMK, Yu J, To KF, Kang W. Chen B, et al. Clin Transl Med. 2023 Nov;13(11):e1481. doi: 10.1002/ctm2.1481. Clin Transl Med. 2023. PMID: 37983931 Free PMC article.
The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas.
Chen B, Chan WN, Xie F, Mui CW, Liu X, Cheung AHK, Lung RWM, Chow C, Zhang Z, Fang C, Yu P, Shi S, Zhou S, Chen G, Wang Z, Wang S, Ding X, Huang B, Liang L, Dong Y, Wong CC, Wu WKK, Cheng ASL, Wong N, Yu J, Lo KW, Tse GMK, Kang W, To KF. Chen B, et al. Clin Transl Med. 2023 Dec;13(12):e1516. doi: 10.1002/ctm2.1516. Clin Transl Med. 2023. PMID: 38148640 Free PMC article.
STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis.
Xie F, Lyu Y, Chen B, Leung HW, Yu P, Feng T, Fang C, Cheung AHK, Zhou B, Jiang J, Zhang G, Xu D, Li L, Jiang C, Chen J, Zhou Z, An L, Huang B, Zhuang K, Luo X, Leung KT, To CH, Ma BB, Wong CC, Wu WK, Yu J, To KF, Kang W. Xie F, et al. Mol Cancer. 2025 Jul 2;24(1):186. doi: 10.1186/s12943-025-02391-x. Mol Cancer. 2025. PMID: 40604818