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Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.
Panyard DJ, Reus LM, Ali M, Liu J, Deming YK, Lu Q, Kollmorgen G, Carboni M, Wild N, Visser PJ, Bertram L, Zetterberg H, Blennow K, Gobom J, Western D, Sung YJ, Carlsson CM, Johnson SC, Asthana S, Cruchaga C, Tijms BM, Engelman CD, Snyder MP. Panyard DJ, et al. Alzheimers Dement. 2024 Jul;20(7):5044-5053. doi: 10.1002/alz.13848. Epub 2024 May 29. Alzheimers Dement. 2024. PMID: 38809917 Free PMC article.
Synaptic protein CSF levels relate to memory scores in individuals without dementia.
Wesenhagen KEJ, de Leeuw DM, Tomassen J, Gobom J, Bos I, Vos SJB, Martinez-Lage P, Tainta M, Popp J, Peyratout G, Tsolaki M, Vandenberghe R, Freund-Levi Y, Verhey F, Lovestone S, Streffer J, Dobricic V, Blennow K, Scheltens P, Smit AB, Bertram L, Teunissen CE, Zetterberg H, Tijms BM, Visser PJ; Alzheimer’s Disease Neuroimaging Initiative. Wesenhagen KEJ, et al. Alzheimers Res Ther. 2025 Mar 3;17(1):56. doi: 10.1186/s13195-025-01703-z. Alzheimers Res Ther. 2025. PMID: 40033427 Free PMC article.