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134 results

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Page 1
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN. Xiao L, et al. Cell Metab. 2024 Oct 1;36(10):2207-2227.e9. doi: 10.1016/j.cmet.2024.08.006. Epub 2024 Sep 9. Cell Metab. 2024. PMID: 39255799
Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.
Iwasaki K, Lalani B, Kahng J, Carapeto P, Sanjines S, Hela F, Abarca C, Tsuji T, Darcy J, Bartke A, Tseng YH, Kulkarni RN, Aguayo-Mazzucato C. Iwasaki K, et al. Front Endocrinol (Lausanne). 2023 Jun 27;14:1203534. doi: 10.3389/fendo.2023.1203534. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37441495 Free PMC article.
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN. De Jesus DF, et al. Nat Cell Biol. 2024 Mar;26(3):421-437. doi: 10.1038/s41556-024-01368-0. Epub 2024 Feb 26. Nat Cell Biol. 2024. PMID: 38409327 Free PMC article.
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Patel SJ, et al. Sci Transl Med. 2022 Mar 23;14(637):eabh3831. doi: 10.1126/scitranslmed.abh3831. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320000 Free PMC article.
Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.
Wang X, Li Y, Qiang G, Wang K, Dai J, McCann M, Munoz MD, Gil V, Yu Y, Li S, Yang Z, Xu S, Cordoba-Chacon J, De Jesus DF, Sun B, Chen K, Wang Y, Liu X, Miao Q, Zhou L, Hu R, Ding Q, Kulkarni RN, Gao D, Blüher M, Liew CW. Wang X, et al. Nat Commun. 2022 Nov 28;13(1):7323. doi: 10.1038/s41467-022-34259-9. Nat Commun. 2022. PMID: 36443308 Free PMC article.
Epigenetics in β-cell adaptation and type 2 diabetes.
Kim H, Kulkarni RN. Kim H, et al. Curr Opin Pharmacol. 2020 Dec;55:125-131. doi: 10.1016/j.coph.2020.10.008. Epub 2020 Nov 21. Curr Opin Pharmacol. 2020. PMID: 33232934 Free PMC article. Review.
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways.
Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Basile G, et al. Cell Metab. 2023 Jul 11;35(7):1242-1260.e9. doi: 10.1016/j.cmet.2023.05.007. Epub 2023 Jun 19. Cell Metab. 2023. PMID: 37339634 Free PMC article.
ROCK1 regulates insulin secretion from β-cells.
Sung BJ, Lim SB, Yang WM, Kim JH, Kulkarni RN, Kim YB, Lee MK. Sung BJ, et al. Mol Metab. 2022 Dec;66:101625. doi: 10.1016/j.molmet.2022.101625. Epub 2022 Oct 29. Mol Metab. 2022. PMID: 36374631 Free PMC article.
134 results