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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy.
Cell Rep. 2023 Feb 28;42(2):112037. doi: 10.1016/j.celrep.2023.112037. Epub 2023 Jan 25.
Cell Rep. 2023.
PMID: 36701233
Free PMC article.
SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27.
Gallagher ER, Holzbaur ELF.
Gallagher ER, et al.
Autophagy. 2023 Nov;19(11):3029-3030. doi: 10.1080/15548627.2023.2210943. Epub 2023 May 16.
Autophagy. 2023.
PMID: 37194327
Free PMC article.
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Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27.
Gallagher ER, Oloko PT, Fitch TC, Brown EM, Spruce LA, Holzbaur ELF.
Gallagher ER, et al.
Curr Biol. 2024 Dec 16;34(24):5739-5757.e8. doi: 10.1016/j.cub.2024.10.061. Epub 2024 Nov 13.
Curr Biol. 2024.
PMID: 39541976
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