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Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells.
Ippolito MR, Zerbib J, Eliezer Y, Reuveni E, Viganò S, De Feudis G, Shulman ED, Savir Kadmon A, Slutsky R, Chang T, Campagnolo EM, Taglietti S, Scorzoni S, Gianotti S, Martin S, Muenzner J, Mülleder M, Rozenblum N, Rubolino C, Ben-Yishay T, Laue K, Cohen-Sharir Y, Vigorito I, Nicassio F, Ruppin E, Ralser M, Vazquez F, Santaguida S, Ben-David U. Ippolito MR, et al. Cancer Discov. 2024 Dec 2;14(12):2532-2553. doi: 10.1158/2159-8290.CD-23-0309. Cancer Discov. 2024. PMID: 39247952 Free PMC article.
High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors.
Zheng S, Raz L, Zhou L, Cohen-Sharir Y, Tian R, Ippolito MR, Gianotti S, Saad R, Wardenaar R, Broekhuis M, Suarez Peredo Rodriguez M, Wobben S, van den Brink A, Bakker P, Santaguida S, Foijer F, Ben-David U. Zheng S, et al. EMBO Rep. 2025 Feb;26(4):1036-1061. doi: 10.1038/s44319-024-00363-8. Epub 2025 Jan 21. EMBO Rep. 2025. PMID: 39838194 Free PMC article.