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Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.
Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS; 23andMe Research Team; Million Veteran Program; Concato J, Polimanti R, Gelernter J. Levey DF, et al. Nat Neurosci. 2021 Jul;24(7):954-963. doi: 10.1038/s41593-021-00860-2. Epub 2021 May 27. Nat Neurosci. 2021. PMID: 34045744 Free PMC article.
Exploring the genetic overlap between twelve psychiatric disorders.
Romero C, Werme J, Jansen PR, Gelernter J, Stein MB, Levey D, Polimanti R, de Leeuw C, Posthuma D, Nagel M, van der Sluis S. Romero C, et al. Nat Genet. 2022 Dec;54(12):1795-1802. doi: 10.1038/s41588-022-01245-2. Epub 2022 Dec 5. Nat Genet. 2022. PMID: 36471075
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.
Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H; Department of Veterans Affairs Cooperative Studies Program (no. 575B); VA Million Veteran Program; Polimanti R, Concato J, Gelernter J. Stein MB, et al. Nat Genet. 2021 Feb;53(2):174-184. doi: 10.1038/s41588-020-00767-x. Epub 2021 Jan 28. Nat Genet. 2021. PMID: 33510476 Free PMC article.
Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder.
Mundy J, Hübel C, Gelernter J, Levey D, Murray RM, Skelton M, Stein MB; Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium; Vassos E, Breen G, Coleman JRI. Mundy J, et al. Psychol Med. 2021 Jun 4;52(16):1-10. doi: 10.1017/S0033291721000830. Online ahead of print. Psychol Med. 2021. PMID: 34085609 Free PMC article.
Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition.
Muniz Carvalho C, Wendt FR, Pathak GA, Maihofer AX, Stein DJ, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Muniz Carvalho C, et al. Neurobiol Stress. 2021 Sep 17;15:100400. doi: 10.1016/j.ynstr.2021.100400. eCollection 2021 Nov. Neurobiol Stress. 2021. PMID: 34611531 Free PMC article.
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. Zhou H, et al. Nat Neurosci. 2020 Jul;23(7):809-818. doi: 10.1038/s41593-020-0643-5. Epub 2020 May 25. Nat Neurosci. 2020. PMID: 32451486 Free PMC article.