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Page 1
Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores.
Abramowitz SA, Boulier K, Keat K, Cardone KM, Shivakumar M, DePaolo J, Judy R, Bermudez F, Mimouni N, Neylan C, Kim D, Rader DJ, Ritchie MD, Voight BF, Pasaniuc B, Levin MG, Damrauer SM; Penn Medicine BioBank. Abramowitz SA, et al. JAMA. 2025 Jan 7;333(1):60-70. doi: 10.1001/jama.2024.23784. JAMA. 2025. PMID: 39549270 Free PMC article.
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.
Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dilitikas O, Hoffman-Andrews L, Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P; Penn Medicine Biobank; Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM. Lee DSM, et al. Nat Genet. 2025 Apr;57(4):829-838. doi: 10.1038/s41588-025-02140-2. Epub 2025 Apr 7. Nat Genet. 2025. PMID: 40195560
Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.
Seagle HM, Akerele AT, DeCorte JA, Hellwege JN, Breeyear JH, Kim J, Levin M, Khodurksy S, Bress A, Lee K, Meiler J, Gill D, Lee JS, Heberer K, Miller DR, Reaven P, Chang KM, Lynch JA, Khankari NK, Shuey MM, Edwards TL, Vujkovic M. Seagle HM, et al. medRxiv [Preprint]. 2025 Feb 21:2025.02.18.25321035. doi: 10.1101/2025.02.18.25321035. medRxiv. 2025. PMID: 40034783 Free PMC article. Preprint.
Trans-ancestry genome-wide association meta-analysis of gallstone disease.
Lim J, Vujkovic M, Levin MG, Lorenz K, Voight BF, Zhang DY, Dudek MF, Pahl MC, Pippin JA, Su C, Manduchi E, Wells AD, Grant SFA, Abramowitz S, Damrauer SM, Mukherjee S, Yang G, Kaplan DE; Penn Medicine BioBank; Rader DJ. Lim J, et al. medRxiv [Preprint]. 2025 Mar 17:2025.03.16.25324077. doi: 10.1101/2025.03.16.25324077. medRxiv. 2025. PMID: 40166541 Free PMC article. Preprint.
Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks.
Levin MG, Koyama S, Woerner J, Zhang DY, Rodriguez A, Nandi T, Truong B, Abramowitz SA, Gupta H, Kamineni H, Hornsby W, Li Z, Cohron T, Huffman JE, Ellinor P, Kim D, Liao KP, Madduri RK, Voight BF, Verma A, Damrauer SM, Natarajan P. Levin MG, et al. medRxiv [Preprint]. 2025 May 21:2025.04.18.25326074. doi: 10.1101/2025.04.18.25326074. medRxiv. 2025. PMID: 40313291 Free PMC article. Preprint.