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FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer.
Tai Y, Chow A, Han S, Coker C, Ma W, Gu Y, Estrada Navarro V, Kandpal M, Hibshoosh H, Kalinsky K, Manova-Todorova K, Safonov A, Walsh EM, Robson M, Norton L, Baer R, Merghoub T, Biswas AK, Acharyya S. Tai Y, et al. EMBO Mol Med. 2024 Aug;16(8):1957-1980. doi: 10.1038/s44321-024-00094-2. Epub 2024 Jul 2. EMBO Mol Med. 2024. PMID: 38956205 Free PMC article.
PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.
Yadav M, AlQazzaz MA, Ciamponi FE, Ho JC, Maron MI, Sababi AM, MacLeod G, Ahmadi M, Bullivant G, Tano V, Langley SR, Sánchez-Osuna M, Sachamitr P, Kushida M, Bardile CF, Pouladi MA, Kurtz R, Richards L, Pugh T, Tyers M, Angers S, Dirks PB, Bader GD, Truant R, Massirer KB, Barsyte-Lovejoy D, Shechter D, Harding RJ, Arrowsmith CH, Prinos P. Yadav M, et al. Nucleic Acids Res. 2025 Apr 22;53(8):gkaf347. doi: 10.1093/nar/gkaf347. Nucleic Acids Res. 2025. PMID: 40304179 Free PMC article.
The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity.
Wood TWP, Henriques WS, Cullen HB, Romero M, Blengini CS, Sarathy S, Sorkin J, Bekele H, Jin C, Kim S, Wang X, Laureau R, Chemiakine A, Khondker RC, Isola JVV, Stout MB, Gennarino VA, Mogessie B, Jain D, Schindler K, Suh Y, Wiedenheft B, Berchowitz LE. Wood TWP, et al. Nat Aging. 2025 May;5(5):765-779. doi: 10.1038/s43587-025-00852-y. Epub 2025 Apr 22. Nat Aging. 2025. PMID: 40263616
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