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Mitochondrial DNA Release in Innate Immune Signaling.
Newman LE, Shadel GS. Newman LE, et al. Annu Rev Biochem. 2023 Jun 20;92:299-332. doi: 10.1146/annurev-biochem-032620-104401. Epub 2023 Mar 31. Annu Rev Biochem. 2023. PMID: 37001140 Free PMC article. Review.
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS. Newman LE, et al. Nat Cell Biol. 2024 Feb;26(2):194-206. doi: 10.1038/s41556-023-01343-1. Epub 2024 Feb 8. Nat Cell Biol. 2024. PMID: 38332353 Free PMC article.