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Plasma Ghrelin and Risks of Sex-Specific, Site-Specific, and Early-Onset Colorectal Cancer: A Mendelian Randomization Analysis.
Hazelwood E, Lopez Manzano C, Vincent EE, Albanes D, Bishop DT, Le Marchand L, Ulrich CM, Peters U, Murphy G, Samadder NJ, Anderson L, Gunter MJ, Murphy N, Van Guelpen B, Papadimitriou N. Hazelwood E, et al. Cancer Epidemiol Biomarkers Prev. 2024 Dec 2;33(12):1727-1732. doi: 10.1158/1055-9965.EPI-24-0926. Cancer Epidemiol Biomarkers Prev. 2024. PMID: 39361354 Free PMC article.
Summary data for colorectal cancer risk were obtained from a recent meta-analysis of several genetic consortia (up to 73,673 cases and 86,854 controls). A two-sample MR approach and several sensitivity analyses were applied. ...CONCLUSIONS: Our study suggests that plasma g …
Summary data for colorectal cancer risk were obtained from a recent meta-analysis of several genetic consortia (up to 73,673 cases an …
Comparison of Bordetella species identification among differing rt-PCR assays in the United States.
Cole M, Simon AK, Faulkner A, Skoff T, Tondella ML, Montero C, Nye MB, Williams M. Cole M, et al. Microbiol Spectr. 2024 Aug 6;12(8):e0078324. doi: 10.1128/spectrum.00783-24. Epub 2024 Jul 9. Microbiol Spectr. 2024. PMID: 38980022 Free PMC article.
IMPORTANCE: When testing specimens collected from patients with suspected pertussis, large-scale commercial laboratories in the United States employ an IS481-based assay that cannot differentiate between Bordetella pertussis and Bordetella holmseii. ...These results …
IMPORTANCE: When testing specimens collected from patients with suspected pertussis, large-scale commercial laboratories in th …
Large-Scale Transcriptomics-Driven Approach Revealed Overexpression of CRNDE as a Poor Survival Prognosis Biomarker in Glioblastoma.
Sorokin M, Raevskiy M, Zottel A, Šamec N, Skoblar Vidmar M, Matjašič A, Zupan A, Mlakar J, Suntsova M, Kuzmin DV, Buzdin A, Jovčevska I. Sorokin M, et al. Cancers (Basel). 2021 Jul 8;13(14):3419. doi: 10.3390/cancers13143419. Cancers (Basel). 2021. PMID: 34298634 Free PMC article.
In addition, despite decades of research, there are no established biomarkers for early disease diagnosis and monitoring of patient response to treatment. High throughput sequencing technologies allow for the identification of unique molecules from large clinically …
In addition, despite decades of research, there are no established biomarkers for early disease diagnosis and monitoring of patient response …
Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset.
Leung YY, Lee WP, Kuzma AB, Nicaretta H, Valladares O, Gangadharan P, Qu L, Zhao Y, Ren Y, Cheng PL, Kuksa PP, Wang H, White H, Katanic Z, Bass L, Saravanan N, Greenfest-Allen E, Kirsch M, Cantwell L, Iqbal T, Wheeler NR, Farrell JJ, Zhu C, Turner SL, Gunasekaran TI, Mena PR, Jin Y, Carter L; Alzheimer's Disease Sequencing Project; Zhang X, Vardarajan BN, Toga A, Cuccaro M, Hohman TJ, Bush WS, Naj AC, Martin E, Dalgard CL, Kunkle BW, Farrer LA, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Wang LS. Leung YY, et al. Alzheimers Dement. 2025 May;21(5):e70237. doi: 10.1002/alz.70237. Alzheimers Dement. 2025. PMID: 40407102 Free PMC article.
INTRODUCTION: The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's disease and related dementias (ADRD) by integrating whole genome sequencing (WGS) with other genetic, phenotypic, and harmo …
INTRODUCTION: The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Al …
Prevalence and founder effect of DRC1 exon 1-4 deletion in Korean patients with primary ciliary dyskinesia.
Kim MJ, Kim S, Chae SW, Lee S, Yoon JG, Kim B, Lee JS, Chae JH, Seong MW, Moon J. Kim MJ, et al. J Hum Genet. 2023 Jun;68(6):369-374. doi: 10.1038/s10038-023-01122-8. Epub 2023 Feb 7. J Hum Genet. 2023. PMID: 36747106
PCD exhibiting dynein regulatory complex subunit 1 (DRC1) exon 1-4 deletion has been reported in several Japanese PCD patients; however, no large scale studies have been performed. Here, we aimed to determine the prevalence and founder effect of this variant in the …
PCD exhibiting dynein regulatory complex subunit 1 (DRC1) exon 1-4 deletion has been reported in several Japanese PCD patients; however, no …
Characterizing spatial epidemiology in a heterogeneous transmission landscape using the spatial transmission count statistic.
Lyu L, Veytsel G, Stott G, Fox S, Dailey C, Damodaran L, Fujimoto K, Brown P, Sealy R, Brown A, Alabady M, Bahl J. Lyu L, et al. Commun Med (Lond). 2025 May 9;5(1):165. doi: 10.1038/s43856-025-00888-6. Commun Med (Lond). 2025. PMID: 40346131 Free PMC article.
Intensive and widespread efforts to collect and sequence SARS-CoV-2 viral samples have enabled the development of comparative genomic approaches to reconstruct spatial transmission history and understand viral transmission across different scales. ...We found that …
Intensive and widespread efforts to collect and sequence SARS-CoV-2 viral samples have enabled the development of comparative genomic …
Mendelian randomization-based observational cohort study on drug targets: Impact of antihypertensive and lipid-lowering therapies on inflammatory cytokines.
Xin J, Xu Z, Zhang F, Sun Y, Wang X, Wu C, Zhao L. Xin J, et al. Medicine (Baltimore). 2025 Mar 7;104(10):e41771. doi: 10.1097/MD.0000000000041771. Medicine (Baltimore). 2025. PMID: 40068040 Free PMC article.
This study assesses the causal effects of antihypertensive and lipid-lowering drugs on inflammatory cytokines using a Mendelian randomization (MR) approach. We conducted a drug-targeted MR analysis using data from large-scale genome-wide association studies a …
This study assesses the causal effects of antihypertensive and lipid-lowering drugs on inflammatory cytokines using a Mendelian randomizatio …