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Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway.

Onda H, Crino PB, Zhang H, Murphey RD, Rastelli L, Gould Rothberg BE, Kwiatkowski DJ. Onda H, et al. Mol Cell Neurosci. 2002 Dec;21(4):561-74. doi: 10.1006/mcne.2002.1184. Mol Cell Neurosci. 2002. PMID: 12504590

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells.

Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, Onda H. Kwiatkowski DJ, et al. Hum Mol Genet. 2002 Mar 1;11(5):525-34. doi: 10.1093/hmg/11.5.525. Hum Mol Genet. 2002. PMID: 11875047

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