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Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset.
Leung YY, Lee WP, Kuzma AB, Nicaretta H, Valladares O, Gangadharan P, Qu L, Zhao Y, Ren Y, Cheng PL, Kuksa PP, Wang H, White H, Katanic Z, Bass L, Saravanan N, Greenfest-Allen E, Kirsch M, Cantwell L, Iqbal T, Wheeler NR, Farrell JJ, Zhu C, Turner SL, Gunasekaran TI, Mena PR, Jin Y, Carter L; Alzheimer's Disease Sequencing Project; Zhang X, Vardarajan BN, Toga A, Cuccaro M, Hohman TJ, Bush WS, Naj AC, Martin E, Dalgard CL, Kunkle BW, Farrer LA, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Wang LS. Leung YY, et al. Alzheimers Dement. 2025 May;21(5):e70237. doi: 10.1002/alz.70237. Alzheimers Dement. 2025. PMID: 40407102 Free PMC article.
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.
Bradley J, Pottier C, da Fonseca EL, Kurup JT, Western D, Wang C, Neupane A, Ray NR, Jean-Francois M, Ali M, Timsina J, Bergmann K, Budde J, Martin ER, Pericak-Vance MA, Cuccaro M, Naj AC, Kunkle BW; Alzheimer's Disease Genetics Consortium (ADGC), Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight‐ADRC); Schellenberg GD, Fernandez V, Haines J, Morris JC, Holtzman DM, Perrin RJ, Reitz C, Beecham GW, Cruchaga C. Bradley J, et al. Alzheimers Dement. 2025 Jun;21(6):e70377. doi: 10.1002/alz.70377. Alzheimers Dement. 2025. PMID: 40556318 Free PMC article.