P30 GM138395/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2021	5
2022	22
2023	32
2024	33
2025	6

1

The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.

Ma W, Jani VP, Song T, Gao C, Gong H, Sadayappan S, Kass DA, Irving TC. Ma W, et al. bioRxiv [Preprint]. 2023 Oct 20:2023.10.18.562891. doi: 10.1101/2023.10.18.562891. bioRxiv. 2023. Update in: PNAS Nexus. 2024 Jan 30;3(2):pgae039. doi: 10.1093/pnasnexus/pgae039. PMID: 37904972 Free PMC article. Updated. Preprint.

2

Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle.

Kooiker KB, Mohran S, Turner KL, Ma W, Martinson A, Flint G, Qi L, Gao C, Zheng Y, McMillen TS, Mandrycky C, Mahoney-Schaefer M, Freeman JC, Costales Arenas EG, Tu AY, Irving TC, Geeves MA, Tanner BCW, Regnier M, Davis J, Moussavi-Harami F. Kooiker KB, et al. Circ Res. 2023 Aug 18;133(5):430-443. doi: 10.1161/CIRCRESAHA.123.322629. Epub 2023 Jul 20. Circ Res. 2023. PMID: 37470183 Free PMC article.

3

Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads.

Hessel AL, Engels NM, Kuehn MN, Nissen D, Sadler RL, Ma W, Irving TC, Linke WA, Harris SP. Hessel AL, et al. Nat Commun. 2024 Mar 23;15(1):2628. doi: 10.1038/s41467-024-46957-7. Nat Commun. 2024. PMID: 38521794 Free PMC article.

4

Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients.

van den Berg M, Shi Z, Claassen WJ, Hooijman P, Lewis CTA, Andersen JL, van der Pijl RJ, Bogaards SJP, Conijn S, Peters EL, Begthel LPL, Uijterwijk B, Lindqvist J, Langlais PR, Girbes ARJ, Stapel S, Granzier H, Campbell KS, Ma W, Irving T, Hwee DT, Hartman JJ, Malik FI, Paul M, Beishuizen A, Ochala J, Heunks L, Ottenheijm CAC. van den Berg M, et al. Sci Transl Med. 2024 Jul 31;16(758):eadg3894. doi: 10.1126/scitranslmed.adg3894. Epub 2024 Jul 31. Sci Transl Med. 2024. PMID: 39083588 Free PMC article.

5

Design of intrinsically disordered protein variants with diverse structural properties.

Pesce F, Bremer A, Tesei G, Hopkins JB, Grace CR, Mittag T, Lindorff-Larsen K. Pesce F, et al. Sci Adv. 2024 Aug 30;10(35):eadm9926. doi: 10.1126/sciadv.adm9926. Epub 2024 Aug 28. Sci Adv. 2024. PMID: 39196930 Free PMC article.

6

The structural OFF and ON states of myosin can be decoupled from the biochemical super- and disordered-relaxed states.

Jani VP, Song T, Gao C, Gong H, Sadayappan S, Kass DA, Irving TC, Ma W. Jani VP, et al. PNAS Nexus. 2024 Jan 30;3(2):pgae039. doi: 10.1093/pnasnexus/pgae039. eCollection 2024 Feb. PNAS Nexus. 2024. PMID: 38328779 Free PMC article.

7

Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States.

Gollapudi SK, Ma W, Chakravarthy S, Combs AC, Sa N, Langer S, Irving TC, Nag S. Gollapudi SK, et al. J Mol Biol. 2021 Nov 19;433(23):167295. doi: 10.1016/j.jmb.2021.167295. Epub 2021 Oct 8. J Mol Biol. 2021. PMID: 34627791 Free PMC article.

8

Cardiac myosin filaments are directly regulated by calcium.

Ma W, Nag S, Gong H, Qi L, Irving TC. Ma W, et al. J Gen Physiol. 2022 Dec 5;154(12):e202213213. doi: 10.1085/jgp.202213213. Epub 2022 Nov 1. J Gen Physiol. 2022. PMID: 36327149 Free PMC article.

9

Structural insights into the formation of repulsive netrin guidance complexes.

Priest JM, Nichols EL, Smock RG, Hopkins JB, Mendoza JL, Meijers R, Shen K, Özkan E. Priest JM, et al. Sci Adv. 2024 Feb 16;10(7):eadj8083. doi: 10.1126/sciadv.adj8083. Epub 2024 Feb 16. Sci Adv. 2024. PMID: 38363837 Free PMC article.

10

Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease.

Ma W, Irving TC. Ma W, et al. Int J Mol Sci. 2022 Mar 11;23(6):3052. doi: 10.3390/ijms23063052. Int J Mol Sci. 2022. PMID: 35328477 Free PMC article. Review.

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