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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS. Newman LE, et al. Nat Cell Biol. 2024 Feb;26(2):194-206. doi: 10.1038/s41556-023-01343-1. Epub 2024 Feb 8. Nat Cell Biol. 2024. PMID: 38332353 Free PMC article.
Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer.
Dufresne S, Kuna RS, Wong K, Komarla A, Rock A, Rosada-Encarnación J, Shen C, Mondal P, Parham LR, Izidro Layng F, Peck KL, Fowler A, Lowy AM, Engle D, Tiriac H, Shaw R, Cosford N, Metallo C, Towers C. Dufresne S, et al. bioRxiv [Preprint]. 2025 Jun 5:2025.05.29.656904. doi: 10.1101/2025.05.29.656904. bioRxiv. 2025. PMID: 40501952 Free PMC article. Preprint.