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Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex.
Niu W, Yu S, Li X, Wang Z, Chen R, Michalski C, Jahangiri A, Zohdy Y, Chern JJ, Whitworth TJ, Wang J, Xu J, Zhou Y, Qin Z, Li B, Gambello MJ, Peng J, Wen Z. Niu W, et al. bioRxiv [Preprint]. 2024 Oct 11:2024.10.07.617121. doi: 10.1101/2024.10.07.617121. bioRxiv. 2024. PMID: 39416123 Free PMC article. Preprint.
Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology.
Xie L, Sheehy RN, Muneer A, Xiong Y, Wrobel JA, Zhang F, Park KS, Velez J, Liu J, Luo YJ, Asrican B, Dong P, Li YD, Damian C, Quintanilla L, Li Y, Xu C, Deshmukh M, Coleman LG Jr, Ming GL, Song H, Wen Z, Jin J, Song J, Chen X. Xie L, et al. Nat Commun. 2025 May 7;16(1):4222. doi: 10.1038/s41467-025-59128-z. Nat Commun. 2025. PMID: 40328756 Free PMC article.
Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
Chen X, Xie L, Sheehy R, Xiong Y, Muneer A, Wrobel J, Park KS, Liu J, Velez J, Luo Y, Li YD, Quintanilla L, Li Y, Xu C, Wen Z, Song J, Jin J, Deshmukh M. Chen X, et al. Res Sq [Preprint]. 2023 Nov 21:rs.3.rs-2743792. doi: 10.21203/rs.3.rs-2743792/v1. Res Sq. 2023. Update in: Nat Commun. 2025 May 7;16(1):4222. doi: 10.1038/s41467-025-59128-z. PMID: 38045363 Free PMC article. Updated. Preprint.