R01 AI139102/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	3
2020	3
2021	2
2022	4
2023	6
2024	4
2025	1

1

Distinct sequential death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling.

Wertman RS, Yost W, Herrmann BI, Bourne CM, Sorobetea D, Go CK, Saller BS, Groß O, Scott P, Rongvaux A, Taabazuing CY, Brodsky IE. Wertman RS, et al. Sci Adv. 2024 Jul 26;10(30):eadl3629. doi: 10.1126/sciadv.adl3629. Epub 2024 Jul 26. Sci Adv. 2024. PMID: 39058785 Free PMC article.

2

TLR priming licenses NAIP inflammasome activation by immunoevasive ligands.

Grayczyk JP, Liu L, Egan MS, Aunins E, Wynosky-Dolfi MA, Canna SW, Minn AJ, Shin S, Brodsky IE. Grayczyk JP, et al. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2412700121. doi: 10.1073/pnas.2412700121. Epub 2024 Nov 18. Proc Natl Acad Sci U S A. 2024. PMID: 39556752 Free PMC article.

3

Effector-triggered immunity and pathogen sensing in metazoans.

Lopes Fischer N, Naseer N, Shin S, Brodsky IE. Lopes Fischer N, et al. Nat Microbiol. 2020 Jan;5(1):14-26. doi: 10.1038/s41564-019-0623-2. Epub 2019 Dec 19. Nat Microbiol. 2020. PMID: 31857733 Free PMC article. Review.

4

Inflammatory monocytes promote granuloma control of Yersinia infection.

Sorobetea D, Matsuda R, Peterson ST, Grayczyk JP, Rao I, Krespan E, Lanza M, Assenmacher CA, Mack M, Beiting DP, Radaelli E, Brodsky IE. Sorobetea D, et al. Nat Microbiol. 2023 Apr;8(4):666-678. doi: 10.1038/s41564-023-01338-6. Epub 2023 Mar 6. Nat Microbiol. 2023. PMID: 36879169 Free PMC article.

5

Blockade of IKK signaling induces RIPK1-independent apoptosis in human macrophages.

Nataraj NM, Sillas RG, Herrmann BI, Shin S, Brodsky IE. Nataraj NM, et al. PLoS Pathog. 2024 Aug 26;20(8):e1012469. doi: 10.1371/journal.ppat.1012469. eCollection 2024 Aug. PLoS Pathog. 2024. PMID: 39186805 Free PMC article.

6

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages.

Egan MS, O'Rourke EA, Mageswaran SK, Zuo B, Martynyuk I, Demissie T, Hunter EN, Bass AR, Chang YW, Brodsky IE, Shin S. Egan MS, et al. Elife. 2025 Mar 27;12:RP90107. doi: 10.7554/eLife.90107. Elife. 2025. PMID: 40162563 Free PMC article.

7

TLR priming licenses NAIP inflammasome activation by immunoevasive ligands.

Grayczyk JP, Egan MS, Liu L, Aunins E, Wynosky-Dolfi MA, Canna S, Minn AJ, Shin S, Brodsky IE. Grayczyk JP, et al. bioRxiv [Preprint]. 2023 May 4:2023.05.04.539437. doi: 10.1101/2023.05.04.539437. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2412700121. doi: 10.1073/pnas.2412700121. PMID: 37205371 Free PMC article. Updated. Preprint.

8

Yersinia Type III-Secreted Effectors Evade the Caspase-4 Inflammasome in Human Cells.

Zhang J, Brodsky IE, Shin S. Zhang J, et al. bioRxiv [Preprint]. 2023 Jun 16:2023.01.24.525473. doi: 10.1101/2023.01.24.525473. bioRxiv. 2023. Update in: mBio. 2023 Oct 31;14(5):e0131023. doi: 10.1128/mbio.01310-23. PMID: 36747770 Free PMC article. Updated. Preprint.

9

Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling.

Wertman RS, Go CK, Saller BS, Groß O, Scott P, Brodsky IE. Wertman RS, et al. bioRxiv [Preprint]. 2023 Sep 15:2023.09.14.557714. doi: 10.1101/2023.09.14.557714. bioRxiv. 2023. Update in: Sci Adv. 2024 Jul 26;10(30):eadl3629. doi: 10.1126/sciadv.adl3629. PMID: 37745613 Free PMC article. Updated. Preprint.

10

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality.

Demarco B, Grayczyk JP, Bjanes E, Le Roy D, Tonnus W, Assenmacher CA, Radaelli E, Fettrelet T, Mack V, Linkermann A, Roger T, Brodsky IE, Chen KW, Broz P. Demarco B, et al. Sci Adv. 2020 Nov 18;6(47):eabc3465. doi: 10.1126/sciadv.abc3465. Print 2020 Nov. Sci Adv. 2020. PMID: 33208362 Free PMC article.

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