R01 AR072999/AR/NIAMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2020	1
2021	9
2022	8
2023	11
2024	11
2025	8

1

The role of PIEZO ion channels in the musculoskeletal system.

Savadipour A, Palmer D, Ely EV, Collins KH, Garcia-Castorena JM, Harissa Z, Kim YS, Oestrich A, Qu F, Rashidi N, Guilak F. Savadipour A, et al. Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C728-C740. doi: 10.1152/ajpcell.00544.2022. Epub 2023 Jan 30. Am J Physiol Cell Physiol. 2023. PMID: 36717101 Free PMC article. Review.

2

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.

Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB. Lee W, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2001611118. doi: 10.1073/pnas.2001611118. Proc Natl Acad Sci U S A. 2021. PMID: 33758095 Free PMC article.

3

Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis.

Tang R, Harasymowicz NS, Wu CL, Choi YR, Lenz K, Oswald SJ, Guilak F. Tang R, et al. Proc Natl Acad Sci U S A. 2024 Oct 22;121(43):e2402954121. doi: 10.1073/pnas.2402954121. Epub 2024 Oct 14. Proc Natl Acad Sci U S A. 2024. PMID: 39401356 Free PMC article.

4

Mechanogenetics: harnessing mechanobiology for cellular engineering.

Nims RJ, Pferdehirt L, Guilak F. Nims RJ, et al. Curr Opin Biotechnol. 2022 Feb;73:374-379. doi: 10.1016/j.copbio.2021.09.011. Epub 2021 Nov 1. Curr Opin Biotechnol. 2022. PMID: 34735987 Free PMC article. Review.

5

Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks.

Dudek M, Pathiranage DRJ, Bano-Otalora B, Paszek A, Rogers N, Gonçalves CF, Lawless C, Wang D, Luo Z, Yang L, Guilak F, Hoyland JA, Meng QJ. Dudek M, et al. Nat Commun. 2023 Nov 14;14(1):7237. doi: 10.1038/s41467-023-42056-1. Nat Commun. 2023. PMID: 37963878 Free PMC article.

6

Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.

Chu CR, Hochberg M, White D, Rodeo S, Huard J, Shapiro S, Lattermann C, Guilak F. Chu CR, et al. Semin Arthritis Rheum. 2025 Apr;71:152652. doi: 10.1016/j.semarthrit.2025.152652. Epub 2025 Feb 3. Semin Arthritis Rheum. 2025. PMID: 39970622 Review.

7

Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes.

Savadipour A, Nims RJ, Rashidi N, Garcia-Castorena JM, Tang R, Marushack GK, Oswald SJ, Liedtke WB, Guilak F. Savadipour A, et al. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2221958120. doi: 10.1073/pnas.2221958120. Epub 2023 Jul 17. Proc Natl Acad Sci U S A. 2023. PMID: 37459546 Free PMC article.

8

A Damaging COL6A3 Variant Alters the MIR31HG-Regulated Response of Chondrocytes in Neocartilage Organoids to Hyperphysiologic Mechanical Loading.

Bloks NG, Harissa Z, Mazzini G, Adkar SS, Dicks AR, Hajmousa G, Steward N, Koning RI, Mulder A, de Koning BBR, Kloppenburg M, de Almeida RC, Ramos YF, Guilak F, Meulenbelt I. Bloks NG, et al. Adv Sci (Weinh). 2024 Sep;11(36):e2400720. doi: 10.1002/advs.202400720. Epub 2024 Jul 17. Adv Sci (Weinh). 2024. PMID: 39021299 Free PMC article.

9

Immunoengineering the next generation of arthritis therapies.

Klimak M, Nims RJ, Pferdehirt L, Collins KH, Harasymowicz NS, Oswald SJ, Setton LA, Guilak F. Klimak M, et al. Acta Biomater. 2021 Oct 1;133:74-86. doi: 10.1016/j.actbio.2021.03.062. Epub 2021 Apr 3. Acta Biomater. 2021. PMID: 33823324 Free PMC article. Review.

10

The chondrocyte "mechanome": Activation of the mechanosensitive ion channels TRPV4 and PIEZO1 drives unique transcriptional signatures.

Nims R, Palmer DR, Kassab J, Zhang B, Guilak F. Nims R, et al. FASEB J. 2024 Jul 15;38(13):e23778. doi: 10.1096/fj.202400883R. FASEB J. 2024. PMID: 38959010

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