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2018 2
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Page 1
The immunology of type 1 diabetes.
Herold KC, Delong T, Perdigoto AL, Biru N, Brusko TM, Walker LSK. Herold KC, et al. Nat Rev Immunol. 2024 Jun;24(6):435-451. doi: 10.1038/s41577-023-00985-4. Epub 2024 Feb 2. Nat Rev Immunol. 2024. PMID: 38308004 Free PMC article. Review.
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.
Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. Zhang SM, et al. Nature. 2021 Oct;598(7882):682-687. doi: 10.1038/s41586-021-03994-2. Epub 2021 Oct 20. Nature. 2021. PMID: 34671158 Free PMC article.
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real BF, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen MW, Kurniawan H, Wagner A, Yosef N, Weiss SNY, Schmetterer KG, Schröder A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois LJ, Brenner D, Kempa S, Hafler DA, Stegbauer J, Linker RA, Jantsch J, Müller DN, Kleinewietfeld M. Côrte-Real BF, et al. Cell Metab. 2023 Feb 7;35(2):299-315.e8. doi: 10.1016/j.cmet.2023.01.009. Cell Metab. 2023. PMID: 36754020 Free article.
An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction.
Sumida TS, Lincoln MR, He L, Park Y, Ota M, Oguchi A, Son R, Yi A, Stillwell HA, Leissa GA, Fujio K, Murakawa Y, Kulminski AM, Epstein CB, Bernstein BE, Kellis M, Hafler DA. Sumida TS, et al. Sci Transl Med. 2024 Aug 28;16(762):eadp1720. doi: 10.1126/scitranslmed.adp1720. Epub 2024 Aug 28. Sci Transl Med. 2024. PMID: 39196959 Free PMC article.
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma.
Lu BY, Lucca LE, Lewis W, Wang J, Nogueira CV, Heer S, Rayon-Estrada V, Axisa PP, Reeves SM, Buitrago-Pocasangre NC, Pham GH, Kojima ML, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski JJ, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle AJ, Kisielow J, Obermair FJ, Kluger HM, Hafler DA. Lu BY, et al. Nat Immunol. 2025 Jan;26(1):82-91. doi: 10.1038/s41590-024-02023-4. Epub 2024 Nov 28. Nat Immunol. 2025. PMID: 39609626
Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes.
Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS, Krishnaswamy S, Herold KC. Perdigoto AL, et al. JCI Insight. 2022 Sep 8;7(17):e156330. doi: 10.1172/jci.insight.156330. JCI Insight. 2022. PMID: 35925682 Free PMC article.
41 results