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Page 1
Tumour-wide RNA splicing aberrations generate actionable public neoantigens.
Kwok DW, Stevers NO, Etxeberria I, Nejo T, Colton Cove M, Chen LH, Jung J, Okada K, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Liu J, Wu SH, Ramos E, Yamamichi A, Watchmaker PB, Ogino H, Saijo A, Du A, Grishanina NR, Woo J, Diaz A, Hervey-Jumper SL, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. Kwok DW, et al. Nature. 2025 Mar;639(8054):463-473. doi: 10.1038/s41586-024-08552-0. Epub 2025 Feb 19. Nature. 2025. PMID: 39972144 Free PMC article.
Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial.
Vos JL, Burman B, Jain S, Fitzgerald CWR, Sherman EJ, Dunn LA, Fetten JV, Michel LS, Kriplani A, Ng KK, Eng J, Tchekmedyian V, Haque S, Katabi N, Kuo F, Han CY, Nadeem Z, Yang W, Makarov V, Srivastava RM, Ostrovnaya I, Prasad M, Zuur CL, Riaz N, Pfister DG, Klebanoff CA, Chan TA, Ho AL, Morris LGT. Vos JL, et al. Nat Med. 2023 Dec;29(12):3077-3089. doi: 10.1038/s41591-023-02518-x. Epub 2023 Aug 24. Nat Med. 2023. PMID: 37620627 Free PMC article. Clinical Trial.
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias.
Kim WJ, Crosse EI, De Neef E, Etxeberria I, Sabio EY, Wang E, Bewersdorf JP, Lin KT, Lu SX, Belleville A, Fox N, Castro C, Zhang P, Fujino T, Lewis J, Rahman J, Zhang B, Winick JH, Lewis AM, Stanley RF, DeWolf S, Urben BM, Takizawa M, Krause T, Molina H, Chaligne R, Koppikar P, Molldrem J, Gigoux M, Merghoub T, Daniyan A, Chandran SS, Greenbaum BD, Klebanoff CA, Bradley RK, Abdel-Wahab O. Kim WJ, et al. Cell. 2025 Jun 26;188(13):3422-3440.e24. doi: 10.1016/j.cell.2025.03.047. Epub 2025 Apr 23. Cell. 2025. PMID: 40273911 Free article.
Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors.
Espinosa-Carrasco G, Scrivo A, Zumbo P, Dave A, Betel D, Hellmann M, Burt BM, Lee HS, Schietinger A. Espinosa-Carrasco G, et al. bioRxiv [Preprint]. 2023 Jul 3:2023.07.03.547423. doi: 10.1101/2023.07.03.547423. bioRxiv. 2023. Update in: Cancer Cell. 2024 Jul 8;42(7):1202-1216.e8. doi: 10.1016/j.ccell.2024.05.025. PMID: 37461721 Free PMC article. Updated. Preprint.