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The Ngal reporter mouse detects the response of the kidney to injury in real time.
Paragas N, Qiu A, Zhang Q, Samstein B, Deng SX, Schmidt-Ott KM, Viltard M, Yu W, Forster CS, Gong G, Liu Y, Kulkarni R, Mori K, Kalandadze A, Ratner AJ, Devarajan P, Landry DW, D'Agati V, Lin CS, Barasch J. Paragas N, et al. Nat Med. 2011 Feb;17(2):216-22. doi: 10.1038/nm.2290. Epub 2011 Jan 16. Nat Med. 2011. PMID: 21240264 Free PMC article.
Mutations in transcription factor CP2-like 1 may cause a novel syndrome with distal renal tubulopathy in humans.
Klämbt V, Werth M, Onuchic-Whitford AC, Getwan M, Kitzler TM, Buerger F, Mao Y, Deutsch K, Mann N, Majmundar AJ, Kaminski MM, Shen T, Schmidt-Ott KM, Shalaby M, El Desoky S, Kari JA, Shril S, Lienkamp SS, Barasch J, Hildebrandt F. Klämbt V, et al. Nephrol Dial Transplant. 2021 Jan 25;36(2):237-246. doi: 10.1093/ndt/gfaa215. Nephrol Dial Transplant. 2021. PMID: 33097957 Free PMC article.
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A, Viltard M, Williams D, Paragas N, Leete T, Kulkarni R, Li X, Lee B, Kalandadze A, Ratner AJ, Pizarro JC, Schmidt-Ott KM, Landry DW, Raymond KN, Strong RK, Barasch J. Bao G, et al. Nat Chem Biol. 2010 Aug;6(8):602-9. doi: 10.1038/nchembio.402. Epub 2010 Jun 27. Nat Chem Biol. 2010. PMID: 20581821 Free PMC article.
Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
Li JY, Paragas N, Ned RM, Qiu A, Viltard M, Leete T, Drexler IR, Chen X, Sanna-Cherchi S, Mohammed F, Williams D, Lin CS, Schmidt-Ott KM, Andrews NC, Barasch J. Li JY, et al. Dev Cell. 2009 Jan;16(1):35-46. doi: 10.1016/j.devcel.2008.12.002. Dev Cell. 2009. PMID: 19154717 Free PMC article.
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