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57 results

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Page 1
Plasticity of the mammalian integrated stress response.
Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, Merrick WC, Komar AA, Koromilas AE, Gorospe M, Payea MJ, Wang F, Clayton BLL, Tesar PJ, Schaffer A, Miron A, Bederman I, Jankowsky E, Vogel C, Valášek LS, Dinman JD, Zhang Y, Tirosh B, Larsson O, Topisirovic I, Hatzoglou M. Chen CW, et al. Nature. 2025 May;641(8065):1319-1328. doi: 10.1038/s41586-025-08794-6. Epub 2025 Mar 26. Nature. 2025. PMID: 40140574 Free PMC article.
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.
Chen CW, Guan BJ, Alzahrani MR, Gao Z, Gao L, Bracey S, Wu J, Mbow CA, Jobava R, Haataja L, Zalavadia AH, Schaffer AE, Lee H, LaFramboise T, Bederman I, Arvan P, Mathews CE, Gerling IC, Kaestner KH, Tirosh B, Engin F, Hatzoglou M. Chen CW, et al. Nat Commun. 2022 Aug 8;13(1):4621. doi: 10.1038/s41467-022-32425-7. Nat Commun. 2022. PMID: 35941159 Free PMC article.
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.
Mucha B, Qie S, Bajpai S, Tarallo V, Diehl JN, Tedeschi F, Zhou G, Gao Z, Flashner S, Klein-Szanto AJ, Hibshoosh H, Masataka S, Chajewski OS, Majsterek I, Pytel D, Hatzoglou M, Der CJ, Nakagawa H, Bass AJ, Wong KK, Fuchs SY, Rustgi AK, Jankowsky E, Diehl JA. Mucha B, et al. Nat Commun. 2022 Nov 3;13(1):6614. doi: 10.1038/s41467-022-34402-6. Nat Commun. 2022. PMID: 36329064 Free PMC article.
Liver stiffness progression in biopsy-proven metabolic dysfunction-associated steatotic disease among people with diabetes versus people without diabetes: A prospective multicenter study.
Huang DQ, Wilson LA, Behling C, Amangurbanova M, Kleiner DE, Kowdley KV, Dasarathy S, Terrault NA, Diehl AM, Chalasani N, Neuschwander-Tetri BA, Sanyal AJ, Tonascia J, Loomba R; NASH Clinical Research Network. Huang DQ, et al. Hepatology. 2025 May 1;81(5):1553-1563. doi: 10.1097/HEP.0000000000001015. Epub 2024 Jul 19. Hepatology. 2025. PMID: 39028908
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M. Jobava R, et al. Mol Cell. 2021 Oct 21;81(20):4191-4208.e8. doi: 10.1016/j.molcel.2021.09.029. Mol Cell. 2021. PMID: 34686314 Free PMC article.
Stem-loop-induced ribosome queuing in the uORF2/ATF4 overlap fine-tunes stress-induced human ATF4 translational control.
Smirnova AM, Hronová V, Mohammad MP, Herrmannová A, Gunišová S, Petráčková D, Halada P, Coufal Š, Świrski M, Rendleman J, Jendruchová K, Hatzoglou M, Beznosková P, Vogel C, Valášek LS. Smirnova AM, et al. Cell Rep. 2024 Apr 23;43(4):113976. doi: 10.1016/j.celrep.2024.113976. Epub 2024 Mar 19. Cell Rep. 2024. PMID: 38507410 Free PMC article.
57 results