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Page 1
IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis.
Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H. Dasgupta D, et al. Gastroenterology. 2020 Oct;159(4):1487-1503.e17. doi: 10.1053/j.gastro.2020.06.031. Epub 2020 Jun 20. Gastroenterology. 2020. PMID: 32574624 Free PMC article.
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.
Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. Li C, et al. Circulation. 2024 Sep 24;150(13):1010-1029. doi: 10.1161/CIRCULATIONAHA.123.067606. Epub 2024 Jun 5. Circulation. 2024. PMID: 38836349
Maternal immune activation in mice disrupts proteostasis in the fetal brain.
Kalish BT, Kim E, Finander B, Duffy EE, Kim H, Gilman CK, Yim YS, Tong L, Kaufman RJ, Griffith EC, Choi GB, Greenberg ME, Huh JR. Kalish BT, et al. Nat Neurosci. 2021 Feb;24(2):204-213. doi: 10.1038/s41593-020-00762-9. Epub 2020 Dec 23. Nat Neurosci. 2021. PMID: 33361822 Free PMC article.
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.
Mawambo G, Oubaha M, Ichiyama Y, Blot G, Crespo-Garcia S, Dejda A, Binet F, Diaz-Marin R, Sawchyn C, Sergeev M, Juneau R, Kaufman RJ, Affar EB, Mallette FA, Wilson AM, Sapieha P. Mawambo G, et al. J Neuroinflammation. 2023 Jun 21;20(1):145. doi: 10.1186/s12974-023-02793-y. J Neuroinflammation. 2023. PMID: 37344842 Free PMC article.
mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory.
Sharma V, Oliveira MM, Sood R, Khlaifia A, Lou D, Hooshmandi M, Hung TY, Mahmood N, Reeves M, Ho-Tieng D, Cohen N, Cheng PC, Rahim MMA, Prager-Khoutorsky M, Kaufman RJ, Rosenblum K, Lacaille JC, Khoutorsky A, Klann E, Sonenberg N. Sharma V, et al. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2308671120. doi: 10.1073/pnas.2308671120. Epub 2023 Nov 28. Proc Natl Acad Sci U S A. 2023. PMID: 38015848 Free PMC article.
eIF2α controls memory consolidation via excitatory and somatostatin neurons.
Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M, Kiniry SJ, Stokes MP, Cohen N, Nelson AJ, Abell K, Possemato AP, Gal-Ben-Ari S, Truong VT, Wang P, Yiannakas A, Saffarzadeh F, Cuello AC, Nader K, Kaufman RJ, Costa-Mattioli M, Baranov PV, Quintana A, Sanz E, Khoutorsky A, Lacaille JC, Rosenblum K, Sonenberg N. Sharma V, et al. Nature. 2020 Oct;586(7829):412-416. doi: 10.1038/s41586-020-2805-8. Epub 2020 Oct 7. Nature. 2020. PMID: 33029011 Free PMC article.
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.
Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, Lévesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman RJ, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N, Gkogkas CG, Khoutorsky A. Hooshmandi M, et al. Neuron. 2023 Oct 4;111(19):3028-3040.e6. doi: 10.1016/j.neuron.2023.06.017. Epub 2023 Jul 19. Neuron. 2023. PMID: 37473758 Free PMC article.
41 results