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PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease.
Nyame K, Xiong J, Alsohybe HN, de Jong APH, Peña IV, de Miguel R, Brummelkamp TR, Hartmann G, Nijman SMB, Raaben M, Simcox JA, Blomen VA, Abu-Remaileh M. Nyame K, et al. Nature. 2025 Jun;642(8067):474-483. doi: 10.1038/s41586-025-08942-y. Epub 2025 May 7. Nature. 2025. PMID: 40335701 Free PMC article.
Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease.
Babygirija R, Sonsalla MM, Mill J, James I, Han JH, Green CL, Calubag MF, Wade G, Tobon A, Michael J, Trautman MM, Matoska R, Yeh CY, Grunow I, Pak HH, Rigby MJ, Baldwin DA, Niemi NM, Denu JM, Puglielli L, Simcox J, Lamming DW. Babygirija R, et al. Nat Commun. 2024 Jun 18;15(1):5217. doi: 10.1038/s41467-024-49589-z. Nat Commun. 2024. PMID: 38890307 Free PMC article.
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Varadharajan V, Ramachandiran I, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Gulshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Elife. 2024 Apr 22;12:RP92243. doi: 10.7554/eLife.92243. Elife. 2024. PMID: 38648183 Free PMC article.
SON-light activation of glucose regulation.
Geoghegan G, Simcox J. Geoghegan G, et al. Cell. 2023 Jan 19;186(2):238-240. doi: 10.1016/j.cell.2022.12.045. Cell. 2023. PMID: 36669471 Free PMC article.
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.
Davidson JW, Jain R, Kizzar T, Geoghegan G, Nesbitt DJ, Cavanagh A, Abe A, Nyame K, Hunger A, Chao X, James I, Walesewicz H, Baldwin DA, Wade G, Michorowska S, Verma R, Schueler K, Hinkovska-Galcheva V, Shishkova E, Ding WX, Coon JJ, Shayman JA, Abu-Remaileh M, Simcox JA. Davidson JW, et al. Cell Metab. 2025 Jun 3;37(6):1413-1425.e6. doi: 10.1016/j.cmet.2025.04.015. Epub 2025 May 14. Cell Metab. 2025. PMID: 40373767 Free article.
21 results