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The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion.
Sukhanov S, Higashi Y, Yoshida T, Mummidi S, Aroor AR, Jeffrey Russell J, Bender SB, DeMarco VG, Chandrasekar B. Sukhanov S, et al. Cell Signal. 2021 Jan;77:109825. doi: 10.1016/j.cellsig.2020.109825. Epub 2020 Nov 4. Cell Signal. 2021. PMID: 33160017 Free PMC article.
Endothelial deficiency of insulin-like growth factor-1 receptor reduces endothelial barrier function and promotes atherosclerosis in Apoe-deficient mice.
Higashi Y, Sukhanov S, Shai SY, Danchuk S, Snarski P, Li Z, Hou X, Hamblin MH, Woods TC, Wang M, Wang D, Yu H, Korthuis RJ, Yoshida T, Delafontaine P. Higashi Y, et al. Am J Physiol Heart Circ Physiol. 2020 Oct 1;319(4):H730-H743. doi: 10.1152/ajpheart.00064.2020. Epub 2020 Aug 14. Am J Physiol Heart Circ Physiol. 2020. PMID: 32795184 Free PMC article.