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A phase 2 study of interleukin-22 and systemic corticosteroids as initial treatment for acute GVHD of the lower GI tract.
Ponce DM, Alousi AM, Nakamura R, Slingerland J, Calafiore M, Sandhu KS, Barker JN, Devlin S, Shia J, Giralt S, Perales MA, Moore G, Fatmi S, Soto C, Gomes A, Giardina P, Marcello L, Yan X, Tang T, Dreyer K, Chen J, Daley WL, Peled JU, van den Brink MRM, Hanash AM. Ponce DM, et al. Blood. 2023 Mar 23;141(12):1389-1401. doi: 10.1182/blood.2021015111. Blood. 2023. PMID: 36399701 Free PMC article. Clinical Trial.
Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage.
Arnhold V, Chang WY, Jansen SA, Thangavelu G, Calafiore M, Vinci P, Fu YY, Ito T, Takashima S, Egorova A, Kuttiyara J, Perlstein A, van Hoesel M, Liu C, Blazar BR, Lindemans CA, Hanash AM. Arnhold V, et al. J Clin Invest. 2024 Feb 13;134(7):e155880. doi: 10.1172/JCI155880. J Clin Invest. 2024. PMID: 38349762 Free PMC article.
STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration.
Takashima S, Sharma R, Chang W, Calafiore M, Fu YY, Jansen SA, Ito T, Egorova A, Kuttiyara J, Arnhold V, Sharrock J, Santosa E, Chaudhary O, Geiger H, Iwasaki H, Liu C, Sun J, Robine N, Mazutis L, Lindemans CA, Hanash AM. Takashima S, et al. Nat Commun. 2025 Jan 2;16(1):138. doi: 10.1038/s41467-024-55227-5. Nat Commun. 2025. PMID: 39746933 Free PMC article.
Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function.
Jansen SA, Cutilli A, de Koning C, van Hoesel M, Sierra LS, Nierkens S, Mokry M, Nieuwenhuis EES, Hanash AM, Mocholi E, Coffer PJ, Lindemans CA. Jansen SA, et al. bioRxiv [Preprint]. 2023 Apr 30:2023.04.30.538862. doi: 10.1101/2023.04.30.538862. bioRxiv. 2023. Update in: iScience. 2024 May 22;27(6):110072. doi: 10.1016/j.isci.2024.110072. PMID: 37163028 Free PMC article. Updated. Preprint.