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Page 1
Genetic risk converges on regulatory networks mediating early type 2 diabetes.
Walker JT, Saunders DC, Rai V, Chen HH, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE; HPAP Consortium; Parker SCJ, Powers AC, Brissova M. Walker JT, et al. Nature. 2023 Dec;624(7992):621-629. doi: 10.1038/s41586-023-06693-2. Epub 2023 Dec 4. Nature. 2023. PMID: 38049589 Free PMC article.
A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.
Lee S, Miller CL, Bentley AR, Brown MR, Nagarajan P, Noordam R, Morrison J, Schwander K, Westerman K, Kho M, Kraja AT, de Vries PS, Ammous F, Aschard H, Bartz TM, Do A, Dupont CT, Feitosa MF, Gudmundsdottir V, Guo X, Harris SE, Hikino K, Huang Z, Lefevre C, Lyytikäinen LP, Milaneschi Y, Nardone GG, Santin A, Schmidt H, Shen B, Sofer T, Sun Q, Tan YA, Tang J, Thériault S, van der Most PJ, Ware EB, Weiss S, Ya Xing W, Yu C, Zhao W, Ansari MAY, Anugu P, Attia JR, Bazzano LA, Bis JC, Breyer M, Cade B, Chen G, Collins S, Corley J, Davies G, Dörr M, Du J, Edwards TL, Faquih T, Faul JD, Fohner AE, Fretts AM, Gangireddy S, Gepner A, Graff M, Hofer E, Homuth G, Hood MM, Jie X, Kähönen M, Kardia SL, Karvonen-Gutierrez CA, Launer LJ, Levy D, Maheshwari M, Martin LW, Matsuda K, McNeil JJ, Nolte IM, Okochi T, Raffield LM, Raitakari OT, Risch L, Risch M, Roux AD, Ruiz-Narvaez EA, Russ TC, Saito T, Schreiner PJ, Scott RJ, Shikany J, Smith JA, Snieder H, Spedicati B, Tai ES, Taylor AM, Taylor KD, Tesolin P, van Dam RM, Wang R, Wenbin W, Xie T, Yao J, Young KL, Zhang R, Zonderman AB; Biobank Japan Project; Lifelines Cohort Study; Concas MP, Conen D, Cox SR, Evans MK, Fox ER, de Las Fuentes L, Giri… See abstract for full author list ➔ Lee S, et al. Res Sq [Preprint]. 2025 Feb 17:rs.3.rs-6025759. doi: 10.21203/rs.3.rs-6025759/v1. Res Sq. 2025. PMID: 40034430 Free PMC article. Preprint.
Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci.
Xu H, Gupta S, Dinsmore I, Kollu A, Cawley AM, Anwar MY, Chen HH, Petty LE, Seshadri S, Graff M, Below P, Brody JA, Chittoor G, Fisher-Hoch SP, Heard-Costa NL, Levy D, Lin H, Loos RJ, Mccormick JB, Rotter JI, Mirshahi T, Still CD, Destefano A, Cupples LA, Mohlke KL, North KE, Justice AE, Liu CT. Xu H, et al. medRxiv [Preprint]. 2024 Jun 12:2024.06.11.24308730. doi: 10.1101/2024.06.11.24308730. medRxiv. 2024. PMID: 38903089 Free PMC article. Preprint.
Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts.
Anwar MY, Graff M, Highland HM, Smit R, Wang Z, Buchanan VL, Young KL, Kenny EE, Fernandez-Rhodes L, Liu S, Assimes T, Garcia DO, Daeeun K, Gignoux CR, Justice AE, Haiman CA, Buyske S, Peters U, Loos RJF, Kooperberg C, North KE. Anwar MY, et al. Hum Genet. 2023 Oct;142(10):1477-1489. doi: 10.1007/s00439-023-02593-7. Epub 2023 Sep 1. Hum Genet. 2023. PMID: 37658231 Free PMC article.
Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height.
Papadopoulou A, Litkowski EM, Graff M, Wang Z, Smit RAJ, Chittoor G, Dinsmore I, Josyula NS, Lin M, Shortt J, Zhu W, Vedantam SL, Yengo L, Wood AR, Berndt SI, Holm IA, Mentch FD, Hakonarson H, Kiryluk K, Weng C, Jarvik GP, Crosslin D, Carrell D, Kullo IJ, Dikilitas O, Hayes MG, Wei W-, Edwards DRV, Assimes TL, Hirschhorn JN, Below JE, Gignoux CR, Justice AE, Loos RJF, Sun YV, Raghavan S, Deloukas P, North KE, Marouli E. Papadopoulou A, et al. NPJ Genom Med. 2025 Feb 27;10(1):14. doi: 10.1038/s41525-025-00464-w. NPJ Genom Med. 2025. PMID: 40016231 Free PMC article.